Grand High Witch

'''"Better is no good either! I demand maximum results!"

- The Grand High Witch to her followers. "Y-you're doomed, old woman! You're doomed forever!"

- Eva Ernst (Grand High Witch) to pointing her spoon at Helga as her witches turn into mice.  The Grand High Witch is the chief antagonist of The Witches and is one of the most influential witches in the world, carefully and cleverly disguised as an attractive and imposing aristocratic-looking woman named Eva Ernst'''. In the film adaptation she was played by Anjelica Huston.

History
Since being one of the most infuential and powerful sorceresses on Earth, she leads a secret society of like-minded witches in their neverending quest to kill and torture children: depiction of witches in this story was considerably dark for a children's book and they were all guilty of child-abuse and murder. She also has an assistant named Anne Irvine, who, unlike the other witches, didn't seem enthusiastic about killing children.

The Grand High Witch especially had a plan that would climax in turning all the children of the world into mice, to be disposed of either by the witches themselves, or by their unsuspecting parents.

In the end, however, the Grand High Witch suffered a somewhat fitting demise when her own magic was used against her and she was transformed (along with many of her followers, except Anne Irvine) into a mouse and killed.

Trivia

 * It should be noted that while in the book, the Grand High Witch is the first witch to transform into a mouse, in the movie she is the last (unless you count Anne Irvine, who didn't transform at all).
 * Unlike the other witches, who at least show a little concern for adults, she shows no compassion for them, shown when a witch asks what would happen if an adult consumed their formula and the Grand High Witch replies "then that's just to bad for the grownup".
 * In the book, the Grand High Witch doesn't take off her gloves, wig or shoes, implying she has more to hide, but in the film, she does.