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Major-Domo is the main antagonist of Wes Anderson's 2018 stop-motion film Isle of Dogs. He is secondary in position to Mayor Kobayashi and wants to exterminate dogs even more than he does.

He was voiced by Akira Takayama in Japanese and Steve Buscemi in English.

Role
Major-Domo takes a relatively minor secondary role to Mayor Kobayashi throughout the film, only appearing whenever he does and not acting on his own accord. His role in the film becomes more major in its climax, where while Kobayashi has a change of heart, Domo insists on going through with the extermination of all dogs and a fight ensues.

Domo successfully presses the button, but thanks to a friend of Tracy Walker, the poison backfires and is unleashed on the captors. Domo's final scene is of him in prison at the end of the film: where dogs have been re-allowed into society, the offending humans have been locked away.

Personality
Domo is a cruel, horrible man: while this is not readily apparent, he has Kobayashi under his thumb and is a big hand in much of the conspiracies going on throghout the movie. He is willing to seriously harm anyone who gets in his way to achieve his goal, shown when he started a fight with Kobayashi over the button that would have annihilated the dog race.

Appearance
His vile appearance could be considered a hint to his true nature: a vile, pale looking thing, hardly resembling a human in everything but basic shape. His head is long and rectangular, his lips are chipped and black and his skin is that of a ghostly pure white. This is of a major contrast to the Mayor, who has a completely normal appearance.