Chimera (Fullmetal Alchemist)

Throughout Fullmetal Alchemist media, Chimera appear as antagonists on the Elric Brothers' path to finding the Philosopher's Stone.

Cornello's Chimera
In the first episode of the 2003 anime series and third of the 2009 series, Cornello reveals a monstrous leonine chimera as one of the fruits of his false Philosopher's Stone. He sends it to attack Edward but it fails to kill him when it bites into his automail arm, giving him a chance to strike it down. Its corpse is later picked clean by Gluttony.

It also serves as the first boss of Fullmetal Alchemist 2: Curse of the Crimson Elixir, being the first scenario wherein Edward can use the alchemical skill to create the lance he uses against it.

Tucker's Chimera
In addition to transforming his wife and daughter into chimera, Shou Tucker also created other chimera that serve as antagonists.

2003 Anime
During the Laboratory 5 arc, it is revealed that Tucker, who has become a chimer himself, has created several to serve as guards in lab, summoning them and ordering them to attack with a whistle. After being reinstated into the military under Frank Archer's commands, Tucker creates chimera for the soldiers. King Bradley orders him to send out a group on a raid in Liore along with Solf J. Kimblee and a few others are sicced on Roy Mustang, Riza Hawkeye, and Alex Louis Armstrong when they catch onto Archer's plot. A canine one in particular demonstrated the ability to speak, saying all those that crossed them would perish. They are slaughtered by Scar

Fullmetal Alchemist 2: Curse of the Crimson Elixir
As the Elric Brothers investigate the Tucker estate following Shou and Nina's deaths, they come across vicious frill lizard-like chimera that serve as cannon fodder of the level.

Father's Chimera
Chimera are also used by Father to guard the pathways leading to his chambers below Central and kill any and all intruders that attack. Scar and Mei Lin kill several on their route to Father. One in particular is a three-headed canine resembling Cerberus, the guardian dog of the Underworld.

Fullmetal Alchemist and the Broken Angel
Three bizarre chimera serve as bosses in the game Fullmetal Alchemist and the Broken Angel. The first is a massive drooling frog-like beast that must defeated by throwing bombs into its gullet. The second is a sea serpent. The third is a massive firebird/phoenix-esque beast.