Sally Struthers (South Park)

Sally Struthers is another real-world celebrity that was transformed into a villain by South Park, this is of course nothing like the real Struthers but should be considered a parody (like most South Park villains).

Sally Struthers was the chief antagonist of the episode "Starvin' Marvin" and was depicted as an extremely obese and greedy woman who stole food from the starving population of Ethiopia while pretending to be an activist for change.

Struthers greed was immense in South Park, to the point she defended every morsel of ill-gotten food and became infuriated at even a single piece of her mountain of food being stolen - somewhat ironically it was Cartman (normally an antagonist himself) who would expose her as a fraud, causing the starving population to stage a revolt against their gluttonous overlord.