Medusa


 * Medusa (Soul Eater) - major antagonist from the anime / manga Soul Eater
 * Medusa (Rosario + Vampire) - antagonist in the Japanese manga
 * Medusa (Dungeons & Dragons) - a monstrous humanoid
 * Medusa (Mythology) - cursed monster of Greek mythology
 * Madame Medusa - antagonist of the Disney film Rescuers