God (The Simpsons)

God is the Almighty Ruler of the Universe and main boss in The Simpsons Game.

The Simpsons Game
God serves as the final boss to The Simpsons. He uses previous enemies encountered as icons in a "Guitar Hero"/"Dance Dance Revolution" match, while the chosen song ("Rock you Like a Hurricane", by the Scorpions) plays. As the whole family, you have to make them hit the notes in a correct time to break the game stations and defeat the minions he sends. They will change when the station is broken. Each station is a parody of a popular videogame console (i.e.: Praystation is a parody of PlayStation and the Hii is a parody of the Wii).

Treehouse of Horror XXII
Simpson's roof is torn off and the real God chokes Homer to death. Marge comes in and asks if God can fix everything, but God says the Devil wouldn't like it. The Devil appears with Maude, and it is shown that God is under the Devil's power when the Devil asks for a coffee.