Isshiki Ōtsutsuki

Isshiki Ōtsutsuki is an Ōtsutsuki clan member who is currently in possession of Jigen. According to Sasuke, Isshiki is the fourth Ōtsutsuki in a temple along with Kaguya Ōtsutsuki, Kinshiki Ōtsutsuki, and Momoshiki Ōtsutsuki. It is speculated by Sasuke that Isshiki is likely paired with Kaguya Ōtsutsuki. Isshiki serves as a major antagonist in Boruto: Naruto Next Generations.

Personality
In his brief appearance, Isshiki reveals to be cruel and obsessed with trying to retrieve the vessel for his own purposes. Isshiki shows little respect for the vessel he inhabits by stating that he is weak for him. Having deemed Jigen's body as weak, Isshiki is interested in using Kawaki as a vessel. Isshiki demonstrates a level of lenience when he had Naruto Uzumaki sealed away for further use in the future than to kill him despite the latter's insults. Isshiki is willing to spare his enemies like Naruto only to capture the Nine-Tails inside of him.

Past
Not much is known about Isshiki's past, but he was stated to be paired with Kaguya Ōtsutsuki. The two arrived on Earth but they split up. Kaguya ends up getting sealed away by her sons, while Isshiki remains on Earth for many centuries without being detected. At some point in time, Isshiki takes possession of Jigen and uses him as one of his vessel for his own purposes.

Plot
With the missing vessel, Kawaki, Jigen tasks Kara with going after and retrieve it. At one point, Jigen express interest when he hears that Boruto has a kama seal from Delta and thinks of Momoshiki and his plans. Jigen visits the Ten-Tails in an alternate space-time and tells it that he is not ready to be eaten by it. Jigen manages to absorb a lot of chakra taking on the form of Isshiki briefly. He later visits the Hidden Leaf Village where he tried to retrieve Kawaki but was unsuccessful and instead encounters and fights Naruto, the Seventh Hokage. Jigen and Naruto goes to another dimension where they fight until Sasuke appears. The two fight against Jigen until he manages to overwhelm them but since the latter expend so much chakra, it awakens Isshiki's personality. Going forth, Jigen refers to himself in the third person. Despite that, Jigen incapacitate both of them with his powers. Jigen prepares to kill Sasuke but the latter left as Naruto tells him to go. Jigen proceeds to seal away Naruto and the Nine-Tails. Jigen expresses interest in retrieving the Nine-Tails for himself. Jigen left Naruto sealed away as Isshiki, himself, states how weak of a vessel Jigen is.