Mio Takamiya

"Un, I bet you’ve already noticed it, but Spirits are humans that received Sephira Crystals. ──No, I’ve distributed my power to them, that statement would be more accurate? Originally, the word Spirit only referred to me, the First Spirit."

- Mio Takamiya introducing herself "But, we have to be careful. Love also could also be, the emotion that will destroy the world."

- Reine Murasame to Kotori Itsuka "You're disappointed of humans. You think this world is hopeless. Do you want power? A power big enough to change the world?"

- Reine as Phantom offering power to a depressed Miku Izayoi

Mio Takamiya (in Japanese: 崇宮澪, Takamiya Mio), but is more known as First Spirit and her Doppelganger, Reine Murasame (in Japanese: 村雨 令音, Murasame Reine) who is also known as Phantom, are the overaching antagonist(s) and the main antagonist of Date A Live franchise as a whole. She is the primary source of all conflict of the entire light novels, mangas, animes and games Date A Live, and by far the biggest threat faced by the protagonists.

Mio is the first Spirit to ever appear on reality, causing the First Spacequake 30 years ago prior the beginning of the series, and then bringing more Spirits to the world. She is also known as the Spirit of Origin, due to her existence being the source for the appearance of other Spirits. As the Mother of All Spirits, she is the one that has been turning humans into Spirits, causing normal humans to become Inverse Spirits in the Spirit Dimension and then turning them into targets of humanity, and mainly of Deus.Ex.Machina Industries.

To keep her eyes over Shinji Takamiya (now reborn as Shido Itsuka), she created a human doppelganger of herself called Reine Murasame and put her as the Head Analyst aboard Ratatoskr's Fraxinus and a non-certified medic who can perform simple first aid tasks. It is revealed in late volumes that Reine is Phantom, the mysterious entity who turned Kotori Itsuka and Miku Izayoi in Spirits.

As Reine Murasame, she was voiced by Aya Endou in Japanese version and by Barrett Nash in the English version. Considering that Mio was never adapted in the anime adaptation yet, she still don't have an actor voice.

Mio Takamiya
Mio is the "First Spirit" born when the Spirit Formula gather all of the world's mana in a single location by the work of Isaac Westcott, Elliot Woodman and Ellen Mathers, thirty years prior. However, her birth involuntarily caused the first spatial quake to occur, which destroyed a huge part of Eurasia. Mio had the mentality of an infant, and continuously fluctuated between reality and another dimension that was created as a result of her birth. Because of this, smaller spatial quake would happen every time she appeared in the world, which would ravage the world a few months after her birth. Her codename is Deus.

One day, she was approached by a boy named Shinji Takamiya, who gave the naked girl his jacket and decided to bring her home with him. Mio received her name of their first meeting, 30th. Shinji also gave her key insight on the concept of love. While living with Shinji and Mana, Mio quickly started to gain self-awareness of the real world by reading books, following the radio and watching television and cassettes. One time, Shinji took Mio around town and told her about everything that caught her attention. Mio was so overjoyed that she cried. Apparently, however, DEM uncovered Mio's location, forcing her to flee with Shinji. While running, Woodman appeared before them, but he allowed them to pass after asking Mio if she is happy being with Shinji. Despite this, Westcott revealed that he had abducted Mana but was willing to trade her for Mio. Denying him, Westcott shot Shinji in the chest using a gun. This caused Mio to finally realizing how much Shinji meant to her and escaped. Her personality changes into demeanor and very melancholic to an extreme goal driven into willingly sacrifice countless humans achieve her wish.

Mio absorbed Shinji's corpse into her and recreates him by nurturing "Shido" in her womb before giving birth to him—becoming his new mother. Her plan was to entrust him with her power so that he could become her eternal lover. Since the body of a normal human is frail to accept all her power at once, Mio only gave Shido the power to take in the Spirit's power. Then, she divided her power, planting them like seeds into young girls in order for Shido to gradually take their powers one by one. However, humans were not compatible with the Qlipha Crystals she created, causing them to turn into monsters and go berserk. Therefore, Mio decided to reverse their properties, turning them into Sephira Crystals to make them more compatible, starting with Nia Honjou. Around this time, Mio successfully gave birth to Shido, and left him to be adopted by the Itsuka family.

At some point, one of the berserk Spirits attacked a young Kurumi Tokisaki, though Mio managed to save her, still willing trick Kurumi into becoming a Spirit under the premise of being an ally of justice who was saving the world from Spirits. One day, however, Kurumi invited Mio over to her friend Sawa Yamauchi's place. This caused Mio to be caught in the act of removing the Qlipha Crystal from the body of the Efreet Spirit, who was revealed to be none other than Sawa. This revelation caused Kurumi to start transforming into her Inverse Form. However, much to Mio's surprise, Kurumi stopped her transformation by using her Fourth Bullet to reverse time and return to a moment before she started feeling overwhelmed by despair. Mio sincerely apologizes and states that she had no ill will towards Kurumi, but she cannot stop until she had entrusted her power to those chosen among humanity.

Reine Murasame
Reine is the analyst onboard the Fraxinus, she is a non-certified medic who can perform simple first aid tasks. On the second day of the semester, she transfers into Shido's school as his assistant homeroom teacher. She is soft spoken, often speaking in a nonchalant manner who seems to have a physically weak stature and always seems to be tired. She even says that she has not slept for 30 years.

It is revealed in Volume 16 that she is the enigmatic entity known as Phantom and Mio's doppelganger. A mysterious entity is who gave humans their Spirit powers. It's heavily implied that Reine is assisting Mio to offer females the Sephira Crystals. This was done by offering them a gem that dissolved into their hands infusing them with the power of a Spirit. Whenever meeting someone Reine always conceals her identity by turning her appearance and voice into 'noise' so while people know she's there and can 'hear' her voice in their minds, nobody can discern or remember what Phantom looked or sounded like (even on camera) so her whole identity, including gender, is hidden. Reine is also the one who told Kurumi about where the "Second Spirit" to show on Earth may be held in along with the information that Shido holds the powers equivalent to three Spirits within him. She stated Origami was the best girl to turn into a Spirit and is surprised that she is rebelling against her.

Trivia

 * Aya Endo, the voice actor of Reine, never dubbed an antagonist character before. After the events of Volume 16, Reine was revealed to be Phantom and a clone of Mio Takamiya. This confirmed Aya's first dub in an antagonist character in her career.
 * Reine has a tendency to faint suddenly due to her suffering from sleep deprivation. This is related to the Spacequake of 30 years ago, but the reason behind it is unknown even after her death.
 * She cannot pronounce Shido's name, which is why she calls him Shin. This is related to his form persona, Shinji Takamiya. Deep inside, Reine and Mio still love Shinji rather than the actual Shido himself.
 * The kanji for "zero" (零) can be created with the first kanji of her name (令) plus the second kanji of her surname (雨). In the Kaballah, Zero stands for the three mysterious forces located above, and said to be the origin of, the Kaballah's Tree of Life, "En" (Nothingness), "En Sof" (The Infinite), and "Ohr En Sof" (The Infinite Light).
 * Reine's Voice Actor, Aya Endo, also voices Phantom in Date A Live: Rinne Utopia. Confirming her theory as Phantom.
 * When Kotori mentioned Shido was near to being suicidal in the past in Light Novel Volume 1, Reine reacted strangely to this, almost emotional. She also was noticeably angry when she saw the modifications that had been made on Mana's body. ​She also gave a similar reaction when Shido mentioned she was like a mother after she calmed other Spirits whom Natsumi made younger.
 * The name of her angels Ain (אין), Ain Soph (אין סוף), and Ain Soph Aur (אין סוף אור), mean "Nothing", "Infinity" and "Infinite Light" respectively.
 * The name Mio was given to her by Shido, who named her after the 30th, the day where they first met. The katakana mi (ミ) is a phonetic stand-in for three and the katakana o (オ) symbolizes ∅, which can mean either empty set or zero.
 * According to the Afterword of Volume 18, Mio's Astral Dress is based off the concept of a maternity dress.
 * In the English Dub, Reine's name is pronounced as 'Reina'.