Madame Cat

Madame Cat (Real Name Selina Luthor), is a villainess from the Amalgam Universe who is a fusion of Catwoman and Madame Hydra with elements of Lena Luthor and Sin thrown in. She is a member of the Amalgam Universe's version of Hydra and an enemy of SHIELD Agent Bruce Wayne and his associates.

history
Selina Luthor was the daughter of Green Skull (a.k.a: Lex Luthor) and Lois Lane. However, Lois did not want for her daughter to grow up to become a terrorist and a criminal like her father, and tried to protect her from her father's toxic influence. In response, Luthor killed his wife and took his daughter, bringing her up as one of his Hydra minions and indoctrinating her into becoming a Hydra agent.

What Green Skull didn't realize though, was that Selina never forgot or forgave her father for killing her mother, and plotted to revenge herself on him one day. She got her chance when Bruce Wayne sent a S.H.I.E.L.D. strike against one of HYDRA's bases. In the chaos of the battle, Selina killed her father (although it later turned out to have been a double in disguise). With her father seemingly dead and her mother avenged, Selina seized control of Hydra. With the base she and her enemies were in set to explode, the fates of all within, including herself, is unknown.

trivia

 * Though primarily a fusion of Catwoman and Madame Hydra, her being related to Green Skull (who is Lex Luthor fused with Red Skull), would logically mean she also has elements of those two character's respective female relatives (Lena Luthor and Sin, the latter of whom was Red Skull's daughter as Madame Cat is Green Skull's).
 * Ironically, despite being one part Catwoman, the hero with whom she briefly had a romance was not SHIELD Agent Bruce Wayne, but instead Anthony Stark.