Yokoth

Yokoth is a Lovecraftian Deity from another universe who served as the main antagonist in the Supernatural episode The Thing. She was portrayedd by Magda Apanowicz, while possessing the body Sandy Porter.

Background
Yokoth, alongside her mate Glythur, consumed/destroyed most of their own universe, with the help of their children known as the "faceless hordes".

Summoned in 1925
Around the 1925 a group of rogue Men of Letters, led by Diego Avila, performed a ritual with the Seal of Solomon that opened a rift to the universe ruled by Yokoth and Glythur. Avila, a disillusioned World War I-veteran, wanted the Old Ones to come through in order to "cleanse the world of hate and bring a new paradise".

Yokoth game through and started to possess the body of Sandy Porter, a woman the Men of Letters had kidnapped for the ritual. Sandy died from this, and Yokoth devoured Avila and most of the other Men of Letter.

The few survivors managed to close the rift before Glythur could come through as well, and managed to bind Yokoth, so that she could summon her spouse.

Meeting Sam and Dean in 2018
In 2018 she managed to make Sam and Dean Winchester release her, by pretending to be Sandy. Later Sam was captured by the the decendants of Diego Avila, who told him the truth about Yokoth, while Dean was captured by Yokoth who intended to use him as a vessell for Glythur, so that they could devour Sam and Dean's universe.

She had aquired the Seal of Solomon and  managed to open the rift and Glythur's tentacles came through. Sam and the two decendants of Diego Avila came onto the scene and started to fight the cosmic entity. Dean managed to snatch the Seal of Solomon from Yokoth, and started to reverse the ritual, closing the rift. Before the rift was closed Glythur's tentacles dragged Yokoth back to the their universe.

Apperance
Yokoth's true form is vaguely amorphous, cephalopod-like creature, but she manages to posess human-bodies.

Trivia

 * Inspired the Outer Gods.