Mayor Phlegmming

Mayor Charles Phlegmming is the secondary antagonist of Osmosis Jones. He was the mayor of the City of Frank, before being beaten by his political rival.

He was voiced by William Shatner who also voiced Kazar, General Shanker and Two-Face.

History
Phlegmming is first shown in the movie by controlling Frank DeTorre, refraining him from going to the hospital from a stroke caused by Osmosis Jones.

Later, Jones, as well as pill-guard named Drix, comes to Phlegmming, saying that he found a virus called Thrax, and should put the city on high alert. Phlegmming chooses to ignore Jones' warning, a decision that would haunt him later.

After Jones and Drix unwittingly caused a runny nose while trying to chase down Thrax, Phlegmming decides to fire Jones, and orders Drix to leave Frank's body through the bladder. Fortunately, Jones didn't give up, and he, as well as Drix, disobeys Phlegmming's orders and tries to find Thrax.

Later, Thrax infiltrates the brain of Frank, and steals Frank's DNA Keychain. This causes Frank's temperature to rise to hazardous levels, which gives an intense fever to DeTorre, almost causing him to die. Meanwhile, Phlegmming could do nothing but watch as the City of Frank burned to the ground.

Jones chases Thrax onto Shane's false eyelash. There, the two have a confrontation, Jones winning in the end. Jones returns to Frank's brain and restores the City of Frank by putting the DNA Keychain back where it belongs.

Fortunately, after the massive disaster, Phlegmming faces a massive scandal. In the mayor re-election, his rival wins in a landslide, and Phlegmming is demoted to an Intestinal Cleaner.

While working at his new job, Phlegmming presses a button that was labeled with, "Do not click." This caused him to exit Frank's body, as a fart, causing his demise and death.

personality
Phlegmming is an arrogant, careless, and cruel control freak whose only concern is to stabilize his position as Mayor. Everything else he does is only for his own benefit, not for Frank's or his citizens. The only time he is shown feeling regret and remorse for his actions was when his mayoralty was at stake.

Trivia

 * Had he stopped being the Mayor of Frank by the beginning, Frank would have never contracted Thrax.