Kalirama

"I am Kalirama the Undying. Goddess of Death, War and Annihilation. Daughter of Time. Queen of the Cosmic Powers and Mother to the Fates. Bow before me, so that I may sever your heads from your necks!"

- Kalirama

Kalirama is the main antagonist of the Red vs Blue arc "The Shisno Paradox". She is the Goddess of Death, War, and Annihilation and seeks to destroy the Reds and Blues, who are prophesied to become God's protectors of time.

She is voiced by Lydia Mackay, who also provided the English voices for Kuroka from Highschool DxD, Ultear Milkovich from Fairy Tail, Angelina Durless from Black Butler, Sloth from the 2003 Fullmetal Alchemist, Narukami from Kamisama Kiss, etc.

Season 16
Kalirama is first introduced in the episode "Incendiary Incidents", where Shisno (in Donut's body) informs the Reds and Blues that they have been chosen by God himself to go back in time and fix the past so that they might save the future, becoming his warriors and guardians of time. However, Kalirama travels through time and finds them, wielding swards, guns, and a human skull. She proceeds to introduce herself and threaten the teams. She then fires her blaster and destroys the pizza place the teams were headed to, causing them to angrily fire upon her. However, the bullets do nothing. She mocks them and fights back, but Shisno puts up a magical shield to protect them.

Enraged, Kalirama grows to a massive size and attacks the shield with her sword. Shiso gives the Reds and Blues time portal guns, and they all escape in pairs to different time periods. Kalirama eventually breaks through the shield just as Sarge and Simmons escape, leaving just her and Shisno.

Trivia

 * Kalirama's name and appearance both allude to Kali, the Hindu Goddess of Death & Destruction, as evidenced by the fact that she holds a scimitar-like sword in one lower hand and a skull in the other. Her name also means 'black' in Sanskrit, used in the smoke cloud that appears behind her.
 * Kalirama's armor consists of the Helioskrill helmet and Venator body armor from the Halo franchise.