The Intruder (Toonami)

The Intruder is the main antagonist of the 2000 T. I. E. (Total Immersion Event) of the same name. The Intruder was a large red blob-like creature.

The Intruder
The Intruder invaded the Ghost Planet Spaceship Absolution in search of food. It stuck itself on the starboard engine chamber, and it managed to seep through the hull of the ship. The ship's AI, SARA, reports this to TOM, and he goes to try to neutralize the creature. The Intruder attacks him, and sends him flying out of the ship and disables his nuclear reactor.

When TOM managed to get back onto the ship, the Creature managed to eat multiple Clydes, and tripled in size, making itself into a giant. Tom then tried to shoot the creature with a laser so that it wouldn't get to the ship's engine. TOM momentarily stunned the creature, but he was unfortunately absorbed into it.

The Creature eventually devoured most of the engine, but it was stopped when SARA took a copy of TOM's programming, and proceeded to upload the programming into a new TOM, whom she dubbed TOM 2. TOM 2 then sets up two explosive devices that succeeded in cutting the Intruder off of the starboard engine. The Intruder is then sent into the depths of space, never to be seen again.

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 * It is based on the villain from The Blob.