Professor Ratigan

Basil: ''He's a genius, Dawson! A genius twisted for evil! The Napoleon of crime!''

Dawson: As bad as all that, eh?

Basil: ''Worse....Not a corner of London's safe while Ratigan's at large. No evil scheme he wouldn't concoct! No depravity he wouldn't commit. Who knows what dastardly scheme that villains may be plotting even as we speak?''

--Basil and Dawson discussing Professor Ratigan

In Disney's The Great Mouse Detective, Ratigan or Professor Ratigan is the World's Greatest Criminal Mind. He was plotting to be the first as supreme ruler of all Mousedom. Voiced by the late Vincent Price, Professor Ratigan is rated #17 on the Disney List of all-time best villains.

In "The Great Mouse Detective"
In the film, Ratigan plans to use a robot to replace the Queen of England and then have the robot programmed to name him supreme ruler of all Mousedom. He coerces Mr. Flabbersham into building the robot for him by threatening his daughter. He ensures that his henchmen do what he wants by threatening to have them eaten by his cat Felicia if he is displeased. At the end of the film, he is knocked off Big Ben and disappears into the deep chasm below, following a fierce battle with Basil, similar to the Sherlock Homes story "The Final Problem". In the end, the Big Ben clock tower struck twelve, making Ratigan fall to his doom.

Personality
As Basil's archenemy and the primary antagonist of the film, he possesses many of the characteristics of the classic, evil genius, diabolical villain without a single redeeming quality. He is based on Professor James Moriarty from the Sherlock Holmes stories. He is incredibly extravagant in his clothing and his lair, which is filled with champagne, jewels, and luxurious furniture. He is very sophisticated, with his black suit, cravat, and cigarette holder, and is absolutely appalled when he is called a rat. Believing he is much better and more intelligent than common rats, he has anyone who calls him a rat suffer their fate. However, during the climatic seen in the Big Ben clock tower, he sheds his pristine clothes and begins snarling and scratching with sharpened claws and thrashing his tail, revealing the true animal within that he tried so hard to disguise.

Trivia

 * In the episode of Darkwing Duck is In Like Blunt, Professor Ratigan, Felicia and Fidget the Bat Makes a Cameo-Apperances with Island Salad Sea Resort, Which Came Stole S.H.U.S.H. Agency List.
 * Professor Ratigan along with Basil of Baker Street both make cameos in House of Mouse, both voiced by Maurice LaMarche.