Castillo Sermano

Castillo, the creator of the zombies and was the main villain in the movie of the 2003 film House of the Dead. Castillo was a Spanish Priest and a criminal on death row until he made the serum of immortality to live forever. Castillo was hung, but didn't die and was banished from Spain (though it is hinted he escaped by choice). Castillo murdered the captain of the ship he stowed up and its crew. He eventually landed on the island, killed the natives and he continued his experiments for centuries after. Castillo and his zombies murdered anyone who came to the island. He used the dead appendages of the the victims' bodies to put on himself so he can continue moving faster while his zombies became slower and eventually die (for good) while he lives.

In the movie, Alicia and the others fight off his zombies and eventually fight him. Alicia gets into a sword duel with Castillo and he stabs her in the heart. Rudy decapitates Castillo, thinking the fight is over, but Castillo is still alive and his headless body begins to strangle Rudy. Alicia, who is barely alive, crushes the Castillo's head under her feet, finally stopping him. She then seems to die after saying, "Game over fucker!" in a final scoff towards Castillo. It's unknown how long Castillo lived and how many times he cheated death. Alicia finally kills Castillo ends his immortal life for good. However, Rudy takes Castillo's research which causes further gruesome events in the future.

Legacy
Dr. Curien carries on his work by taking his research and the serum and this leads to the House of the Dead game series.