One-Armed Man

"When I came home there was a man in my house!"

- Dr. Richard Kimble, being interrogated about the attacker

"The one-armed man" is the main antagonist in the 1960s television series, The Fugitive as well as the secondary antagonist in the 1993 film of the same name involving a Doctor on the run who was falsey accused of murdering his wife. Both are based on the real life story of Dr. Sam Sheppard. He was portrayed by Bill Raisch in the TV series and Andreas Katsulas in the film. The villain was named #5 in TV Guide's 60 nastiest villains of all time.

The television series
Despite being the main antagonist, The one-armed man was rarely seen in the series, having almost no dialog until season 4 where he begins to have a larger role in the story. He is aware that Kimble is on the run and targeting him and actively attempts to stop him, primarily by tipping off the police to Kimble's whereabouts. He too is on the run and adopts a variety of different aliases and occupations, even working as a bookmaker for the mob. Throughout the series, a number of details are slowly revealed about the mysterious killer such as his age and blood type until his name is unofficially revealed as "Fred Johnson". However, this was never officially confirmed or denied, making the villain all the more mysterious.

The film
In the film version, he is a security guard named Fredrick Sykes who has a prostetic arm. He works for phamacutical company, Devlin Mcgregor. He is sent by the main antagonist to murder Dr. Kimble after Kimble discovers that the company's new drug, Provasic, was causing severe liver damage. He instead murders Kimble's wife. While on the run, Kimble eventually discovers his true identity as well as leading U.S Marshal Samuel Gerard to him, who becomes suspicious of Sykes and begins investigating him. Later, Sykes corners Kimble on an El Train. At that moment, Kimble is simultaniously spotted by a civilian and a transit cop. Skyes kills the cop and tries to kill Kimble but fails when Kimble is able to overpower him due to him only having one arm. He is presumably arrested after Kimble is exonerated.