Nathan (South Park)

Nathan is a villain who appears in South Park and is a fairly rare example of a criminal mastermind who is also noticably disabled: he acts as Jimmy's archenemy in many ways ever since his drug-dealing ways caused Jimmy to become addicted to steroids and severely effected Jimmy's life until he picked up the courage to stop.

Nathan is later seen the leader of the read team at a camp for the disabled and plots to not only cheat his way to success against Jimmy and the blue team but seeks Jimmy's death as he hates him: however his many plans are foiled by his incompetent henchman Mimsy and he ends up hospitalised.

Despite their rivalry Jimmy gives Nathan his crown as a symbol of goodwill but Nathan just professes to hate him more and also threatens Mimsy for his stupidity.