Esmeralda Poofenplotz

"I can't very well take over the world until I'm drop-dead gorgeous."

- Professor Poofenplotz "Curse you, Pinky the Chihuahua!!"

- Professor Poofenplotz after being defeated.

Professor Esmeralda Poofenplotz is a recurring antagonist in the Disney animated show, Phineas and Ferb. She is the nemesis of Pinky, Isabella Garcia-Shapiro's pet chihuahua. She was first mentioned in "Day of the Living Gelatin", later appearing in "Isabella and the Temple of Sap" and "Bee Story" as the main antagonist.

She is voiced by recurring guest star Amanda Plummer.

Role
Poofenplotz has been known of her silly attempts of worldwide domination. Her known schemes so far involve replacing handbags, stealing royal jelly, and searching for strong hairspray (her favorite is "Stiff Beauty" hairspray, which originally was only used by clowns). Needless to say, because of her somewhat arrogant personality, Poofenplotz has failed to know about the flaws of her schemes. And because of that, it has allowed Pinky to defeat her in return, leaving an humiliated Poofenplotz to yell out, "Curse you, Pinky the Chihuahua!", similar to how Heinz Doofenshmirtz says whenever his plans get foiled by Perry the Platypus.

Poofenplotz is concerned about her looks, as she can't take over the world until she feels she looks her best. Doofenshmirtz even wrote her a letter in "Bee Story" where he informed her that her application into membership in L.O.V.E.M.U.F.F.I.N. had been declined due to her schemes being deemed not close to their standards.