Esmeralda Poofenplotz

Esmeralda Poofenplotz, more commonly known as Professor Poofenplotz, is the nemesis of Pinky, Isabella Garcia-Shapiro's pet chihuahua. She was first mentioned in "Day of the Living Gelatin", later appearing in "Isabella and the Temple of Sap" and "Bee Story".

Her known schemes so far involve replacing handbags and searching for strong hairspray (her favorite is "Stiff Beauty" hairspray, which originally was only used by clowns). She is concerned about her looks, as she can't take over the world until she feels she looks her best. Otherwise she shares much of Doofenshmirtz's personality, including having a vehicle which has her head as the main body and saying "Curse you, Pinky the Chihuahua!" when her plans are foiled or go wrong. Doofenshmirtz wrote her a letter in "Bee Story" where he informed her that her application into membership in L.O.V.E.M.U.F.F.I.N. had been declined due to her being deemed not close to their standards.