Dr. Girlfriend

A major antagonist in The Venture Bros, she is known by several names. She is the girlfriend, assisaint and later the wife of The Monarch. Her real name is Sheila. Despite the fact she is clearly a woman, there are rumors that she is transexual, due to her deep voice (which is the result of a smoking addiction). There where times where she tried to start the life as an independent supervillain, to little aviail. She has her own henchmen, named Tim-Tom and Kevin.

Character history
She was introduced into the world of supervillainy by her former lover Hamilton Fantamos and took her place by his side. She fell in love with of of his henchmen, who back then was the Monarch,  before he started his carrer. They had an affair and she eventually left Phantom Limb for him. By the time The Monarch started his carrer, they spent their time antagonizing Dr. Rusty Venture,  and she was even used to attempt to seduce him. Near the end of the first season, they break up and she goes back to the Phantom Limb.

It turns out the Monarch was framed by the Phantom Limb for the murder of a police officer. This was both an act of revenge and an part of a scheme to takeover the Guild of Calamitis Intent. The Monarch's innocence is proven and eventually, Dr. Girlfriend starts having an affair with him again and the two decide to get married. The wedding is attacked by Phantom Limb's forces before Phantom Limb's plan crashes. The Monarch and Dr. Girlfriend go on their honeymoon shortly after.

Once married, the Guild assigns them as the archenemies of Jonas Venture Jr., but The Monarch uses this as a loophole that allows supervillains to antagonize realatives of their nemesis. In season four they help comfert Henchmen 21 after the death of his friend, Henchmen 24, molding him to be their top henchmen "Two Ton Twenty One".