Adam and Alastor

Warlord Dementus.

As of now, Skar King. But we’ll see when Deadpool and Wolverine comes out.

But as far as tv shows go, then Sutekh from Doctor Who (S1 of the Disney Plus Era. He’s much more nightmare inducing than he ever was).

Chameleon for me. I haven't watched movies like Furiosa or Bad Boys or even Dune so I can't say about them. I am not watching Deadpool 3. Movies like Moana 2, Transformers One and Wild Robot may have better villains.

Sister Sage and Joe Kessler

The Stranger (Star Wars)

Uuuhhh idk if this counts but I really liked the design of the monsters in Arcadian

I got multiple so thats why im picking other, Adam, Lute, and Caesar (as of rn)

Either the Harkonnens, like you said, or my own personal picks, Uncle Kiang and Uncle Soei from How to Make Millions Before Grandma Dies.