The Joker

Red Hood technically isn't a villain anymore. So he doesn't count

Yeah, but you can pick him when he WAS a villain.

@Cliff1647

No, the leader of the Kobra cult in DC

Oh, him. Hmm, interesting choice.

Joker

Darkseid (but make it a fair fight)

Red Skull has the Cosmic Cube. It won’t be enough, but good enough. Something like Cosmic Skull from Avengers Assemble.

Trigon?

Oh, god no. If Red Skull has the Cosmic Cube, sure.