I'm surprised why people consider him the main antagonist and Hank the secondary antagonist. I would argue that they are both equal antagonists, similar to Chuck and Lalo in Better Call Saul. Gus is a member of a drug cartel, the head of his own drug business, and a dangerous enemy for Walt. Hank is an agent of the DEA, has more screen time and appearances than Gus, and poses a personal threat to Walt. In my opinion, they can both be considered equal main antagonists. In addition, Gus dies in Season 4, Hank survives him, and Hank is also introduced from the beginning of the show.
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