This is something I wasn't so sure about and so I wanted to ask for people's opinions on this. Does Agents of S.H.I.E.L.D. have a main antagonist of its entire series? I've looked at other shows that have had villains with similar roles, such as Lucifer in Supernatural, Eobard Thawne in The Flash, Chris McLean in Total Drama, Oswald Cobblepot in Gotham or Cigarette-Smoking Man in The X-Files.
I'm not directly implying Grant Ward as the show's main villain just because he's its most memorable. It depends on who's had the biggest impact on the plots in each season, such as Daniel Whitehall or Hive. Also, if there are villains that fit the role, it doesn't need to be just one villain. It can be two as well.
I don't care if there aren't any and the big villains are better off being labelled as major villains, but I just wanted to be sure just in case.