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|“||You little... backstabbing prick!||„|
|~ Madam Carlisle cursing Arthur Edwards.|
She served as the secondary antagonist in World of Assassination trilogy, being one of the three overarching antagonists in HITMAN 2 (2018) (alongside her fellow Partners, Carl Ingram and Marcus Stuyvesant) and the central antagonist in HITMAN III (2021). In the latter case, she serves as the main antagonist in the latter's mission "Death in the Family".
She was voiced by Moir Leslie.
The Carlisle Family was descended from rural nobility, their earliest known ancestor being knighted during the War of the Roses. In the 1850s, one Enchaboid Carlisle made a fortune in the Second Opium War and invested in shipping, railroads and newspapers. They furthered their businesses in the twentifh century to transportation, airlines and broadcasting, many of their businesses surviving to date.
After World War II, Thomas Alexander Carlisle would found the family's most ambitious business to date, being Providence. He and the heads of the Ingram and Stuyvesant families agreed to pool their assets together.
Thomas had three children, those being Montgomery, the eldest, Alexa Christine, the second born and only daughter, and Zachary, the youngest. Overshadowed by her elder brother, Alexa was to set her own path to the top. Graduating from Cambridge at the top of her class, the young woman rose through the male-dominated shipping industry.
Tragedy struck the family after Montgomery fell to his death from the balcony of the Carlisle estate, secretly orchestrated by his two younger siblings. The incident traumatized Zachary, who abandoned his promising career and became a recluse, living in Thornbridge Manor. With his elder son dead and his youngest unstable, Thomas had no choice but to choose his daughter to succeed him as head of the family.
Unrivalled power at her fingertips, Alexa took the position with glee. Ruthlessly ambitious and devilishly manipulative, she orchestrated the War of the Falklands and played both sides of the Cold War. In the '60s, she aided her father in backing an obscure Romanian research facility by the name of "Institute for Human Betterment", headed by the eccentric Otto Wolfgang Ort-Meyer. Her father soon succumbed to Alzheimer's and Alexa Carlisle took her rightful place as Providence's leader alongside her fellow Partners.
For over three decades, Carlisle enjoyed her position as the most powerful person in the world. However, her schemes to create a supervirus and to overthrow the Moroccan government were foiled by master hitman Agent 47 of the International Contract Agency, who was merely completing contracts placed a mysterious Shadow Client. Arthur Edwards, her mysterious second-in-command, chose to lobby the ICA and had them assassinate the Shadow Client's allies and 47 eventually confronted the Shadow Client himself.
The Shadow Client then revealed to Agent 47 that he is Lucas Grey, who, along with Agent 47, was created to be an assassin by Ort-Meyer. 47 and his handler Diana Burnwood turned on Providence and the ICA, kidnapped Edwards and proceeded to hunt Carlisle and her fellow Partners down.
After Edwards was kidnapped, Carlisle faked her death and fled to the Burj Al-Ghazali, but Agent 47 recovered their identities. Carlisle then fled the skyscraper via a helicopter, leaving her two colleagues to die.
Escaping to her Dartmoor estate, Thornbridge Manor, Carlisle reunited with her estranged children, being her eldest son Gregory, her younger son Edward, and her daughter Rebecca, accompanied by Gregory's wife Emma and son Patrick. Upon discovering her brother Zachary dead from an apparent suicide, she hired a private investigator by the name of Phineas Whitmer to investigate his death. Nevertheless, Agent 47 arrived at the manor and assassinated her.
Alexa Carlisle is a cold-hearted, snake-tongued English noblewoman. In her early scenes, she was unamused by Edwards' theatrics in explaining Grey, rudely demanding to know how he knows them. Ruthlessly ambitious, she is more than willing crush any man foolish enough to stand in her way or unlucky enough to just be in it.
Despite this, Carlisle does have redeeming qualities. She is genuinely heartbroken by her brother Zachary's death and if she learns that her brother Montgomery planned to let her take charge of the family, she will be so overcome with guilt that she would commit suicide. She would also follow up on her deal with 47 (as Whitmer) requests the Edwards file.
- Amongst the Partners despited their shared role in Agent 47's origin story, Madam Carlisle is the closest to be the overarching antagonist of Hitman franchise as a whole, because she directly gave orders on Dr. Ort-Meyer to develope his clones (including 47) into assassins.