Before his life as a crime lord, Amos Fortune was a gang leader in his youth. In his later adult years, he became obsessed with luck. He soon discovered the existence of the fictional "luck glands", which determines a person's luck. He later learned how to control luck glands, and he used this to to manipulate his luck.
Once gaining his new-found powers, he reassembled his old gang members and began battling with the Justice League. When the professor first met them, he tried to remove their good-fortune, but was unsuccessful. He was a primary villain of the Justice League until he later abandoned the gang once more.
When Parademons blew up the House of Secrets, Fortune suffered injuries, but survived. However, when he joined Scarecrow from escaping Enclave M, he was thrown from the Secret Six's helicopter by Knockout, after calling her lover, Scandal, a "moronic slut."
Fortunately, Amos survived the helicopter crash, and devised a plot against the league with the aid of The Wizard. As part of his plan, he had the Wizard assist him in luck magics, and he used the hero Wildcat as a pawn after brainwashing him. Wildcar grew stronger with each victory over a JSA member via the luck magic. Vixen and Gypsy helped Stargirl when she went to face him, given they had faced him years before when they were just recruits. After freeing Wildcat, Stargirl absorbed Amos's luck magic energy with her Cosmic Rod's, causing him to balloon to tremendous size before exploding.
Amos later recruited his gang again and began making major profits with the power of his new sidekick, Roulette. She too ran a gambling operation. Together, they sent their goons out to major money making facilities, such as casinos. During this time, Fortune became more hostile, now killing even his own employees. He would do so by setting up a switch in their gear that would kill them once he flipped it. After being confronted by the Justice League yet again, he just barely managed to get away. He escaped to a river boat on the Mississippi River, but was shot down by a widower of one of his goons that he had killed.
In the Smallville series, Amos took the role of a Casino host at a bachelorette party. One of his vehicles had been stolen, so he had Emil Hamilton captured by his minions. Emil refused to tell him that he took it, so he was killed. Later he also kidnapped Lois and Oliver over the loss of an engagement ring.
Later, Chloe arrived and she was also confronted about the theft of his vehicle. A fight broke out where Oliver was able to get the ring back and knock Amos unconscious.
Amos appears to be a middle aged caucasian man, sometimes having hair and sometimes not. His attire consists of elitist clothing branded with symbols relating to playing cards. Other times, he is seen wearing a white robe with other symbols on it.
Most of Amos's personality revolves around the idea of luck, and how he loves to manipulate it. He is very selfish, willing to go so far as to kill those who do not obey or cooperate with him. He surrounds himself with symbols relating to games that revolve around luck, such as playing cards.