"Brain" may be referring to two or more different villains. If you're uncertain which one you're looking for, just flip a coin.
If you came here from a link, please go back and make the right link for one of the villains listed below.

  • B.R.A.I.N. - the machine from the movie 9 that is responsible for wiping out humanity
  • Brain (DC) - DC comic books
  • Brain (Fairy Tail) - the former guild master of Oración Seis, thus the main antagonist of the latter's eponymous arc in the manga/anime series Fairy Tail
  • Brain (Kamen Rider Drive) - one of the main villains in Kamen Rider Drive
  • Brain (Skylanders) - An Brain creature who is the last of the Ancients, and helps Kaos with his Mind Magic powers
  • Brain (Teen Titans) - Best known from the Teen Titans animated series
  • Brain Gremlin - the main antagonist of Gremlins 2: the New Batch
  • Brainiac - Super genius that is one of Superman's antagonists in the DC comics