Brett Wyden is the major antagonist of the 2018 science fiction action film Rampage which is based on a series of arcade games.
He was played by Jake Lacy.
Rampage
Brett Wyden was the dimwitted brother of the antagonist of the film, Claire Wyden who assisted Claire in her research for Energyne. The company specializes in genetic editing, which they would then sell as bioweapons to the highest bidder. When canisters containing evidence of genetic editing crash to Earth, it causes three animals - an albino gorilla (George), a gray wolf (Ralph) and American alligator (Lizzie) respectively - to mutate into gigantic monsters, Brett become worried by this because of the chance of him and his sister being found out for their research. While he was no where near his sister as being genuinely evil and malicious, Brett goes along with her plan of using a transmitter that would emit specific sound frequencies to lure the three gigantic animals to the city. After several civilians would inevitably end up killed by the beasts' rampage, Claire would swoop in and collect samples of the pathogen after the animals were killed. Brett also contributes in the plane that Davis and Kate were on crashing by using the sound waves to awaken George.
The three animals arrive to the city and start to destroy everything in their path whilst trying to find the source of the sound frequencies. When Davis and Kate infiltrate Energyne in search of the antidote, Brett feebly holds the two at gunpoint, threatening to shoot them, but ultimately, Claire is the one who shoots Davis in the leg because of her brother's incompetence. Kate manages to sneak a sample of the antidote into Claire's bag, and she pushes Claire in the direction of George who then swallows her alive. Brett tries to escape Energyne with the incriminating evidence and Claire's pet rat, only to be stopped by Agent Russell. Russell convinces him to hand over the laptop containing the incriminating evidence (and the pet ret) in return for his chance to escape. Brett takes him on his offer and races out of the building only to be killed upon impact by falling debris. It is also revealed that Russell was setting him up to be killed by the debris.