Do you really think you're unique? My world had a Miles Morales too. And your life will end as his did: In pain... and misery... by my hand!
~ Wolf Spider.
Villains hailing from alternate realities, dimensions and/or universes or living in one after permanently altering the space-time continuum or disasters that forced them to leave their original dimensional timestreams. They could also have come from different realities but now choose to reside in others (e.g. Sunset Shimmer, Rick Sanchez).

This can also be applied to Time-Travelers and Reality-Warpers since by altering timelines they often create entirely new universes; due to the complex natures of time- and dimension-travel interactions between them and individuals from current times and/or dimensions cause paradoxes that can make any points in the space-time continuum become their own separate universes altogether.

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