Do you really think you're unique? My world had a Miles Morales too. And your life will end as his did: In pain... and misery... by my hand!
~ Wolf Spider to Kid Arachnid.

Villains either hailing from an alternate reality, dimension or universe or live in one after permanently altering the space-time continuum or due to some disaster that forced them to leave their original timestream. They could also have come from a different reality but now choose to reside in another (e.g. Sunset Shimmer or Rick Sanchez).

This can also be applied to Time-Travelers or Reality-Warpers, since by altering timelines they often create entirely new universes; due to the complex nature of time-traveling interactions between time-travelers and people from current times often cause paradoxes that can cause the timeline the traveler came from to become its own universe.

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