So for the first century, I'll go easy on them; lure them into a false sense of security. And then when they think I'm not so bad, BAM, I'll go full-tyrant on them in the second century! After that, I'll disappear for a millennia and make them wonder if I ever existed to begin with, just to come back and kill them all!
~ Frieza making his plans once he's wished for immortality from the Dragon Balls.
The Nazis? Is that the limit of your vision? The Nazis want to write themselves into the Grail legend, take on the world. Well, they're welcome to it. But I want the Grail itself, the cup that gives everlasting life. Hitler can have the world, but he can't take it with him. I'm going to be drinking my own health after he's gone the way of the dodo.
~ Walter Donovan's plan for the Holy Grail

The quest for immortality is a common motivation for villains, most commonly occurring with old or aging villains, normally it is the fear of death that drives there pursuit. Although the pursuit of immortality itself is not exactly villainous, quite often it comes with a heavy price, such as sacrificing others for them to gain it.

This category also includes those who originally strived for immortality and succeeded, but came to regret it later on.

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