Villains who drive others insane either through superpowers, concentrated effort or even both. Mind-Breakers may do this for evil goals in mind, or sometimes even out of pure sadism. Many villains can cause insanity by supernatural means, some evil brainwashers or psychics are capable of driving people insane with their powers and torturers can force a person to go into madness through their own barbaric methods, usually through intense physical harm and/or psychological abuse.

Mind-Breakers are often seen as extremely evil given that driving someone insane is, needless to say, a horrible and inhumane act. Especially if it is done through the victim's suffering until their mind just cracks. This can be especially bad as some victims cannot be saved from insanity and even if so, are likely to retain serious trauma afterwards.

These villains differ from Psychological Abusers in terms of severity, although they can very easily overlap. If a villain successfully drives someone into insanity, or at the very least; a severe broken state, then they can qualify for this category as well. Good examples include; It, Slender Man, Glitchtrap, Bellatrix Lestrange, Archibald Snatcher, Kai Chisaki and many versions of the Joker.