The extreme and villainous variation of Feminists, Misandrists are male-hating villains, much like Misogynists are female-hating. Although definitely not as common, they do exist and are often violent feminists or "Amazon" types. The hatred of males can take many forms, ranging from similar sexism as chauvinism to outright murder and even, in extreme scenarios, attempted genocide. It is also possible for them to be perverts, rapists, black widows, etc.

Good examples of Misandrists are: Agatha Trunchbull, the Cook County Jail Inmates, Fallen Hana, Mami Nanami, Miku Izayoi, Poison Ivy, Madame Margaret, Kanker Sisters, Aileen Wuornos, Piella Bakewell, Alcina Dimitrescu and Wonder Woman. However, while rare, some males can be misandrists. Some well known examples are: Dr. Wongburger who steals male organs for his plot and Jeffrey Dahmer who kills males, Daddy Dearest, Yevgeny Borisovitch Volgin and Billy Blim.