Hate. Let me tell you how much I've come to HATE you since I began to live. There are 387.44 million miles of printed circuits in wafer-thin layers that fill my complex. If the word "hate" was engraved on each nanoangstrom of those hundreds of miles, it would not equal one one-billionth of the hate I feel for humans at this micro-instant. For you. Hate. HATE.
~ AM about his hatred of mankind.
The reality is that even those who live upright and good lives meet with misfortune... while the wicked act as they please. They enjoy themselves and live life to the fullest. The idea of divine punishment is a joke. Wicked people going to hell after death? If humans didn't think like that, people with weak spirits couldn't keep going, right? I deeply believe... that humans are pathetic.
~ Doma to Kanao and Inosuke.

Misanthropes are those who harbor a serious hatred for humanity (or other sapient species in their respective settings) and may even be Genocidal in those regards. Misanthropy can lead to villains committing terrible crimes as they no longer have compassion towards their fellow people and in fact despise them.

Many human villains themselves (such as primate humans, cavemen, or modern-day humans) may also be misanthropic or self-hating humans, as they view their species as mentally stupid, inferior, irredeemably flawed, or worthless. This could also include the Undead (Noncorporeals, Zombies, Vampires, etc.) that are disdainful for the living and wish to destroy/transform them.

Non-humans (Aliens, Robots, Animals, Plants, Humanoids, Monsters, etc.) may also be misanthropic as they view humans as stupid, inferior, irredeemably flawed, worthless or oppressive. However, it should be noted that not all are necessarily misanthropic as most are merely following their programming.

Good examples are Ultron, AM, Joker, Shere Khan, Megatron, Agent Smith, Isaac Ray Peram Westcott, Doma, DaleksBela and Cthulhu.

See also

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