Misogynists are female-hating villains who are known for misogyny. It can be physical or emotional abuse specifically towards women, or it may be a deep-rooted prejudice against equal rights. A misogynist may see girls and women as evil, debased, or even subhuman and mere objects (though they may make certain exceptions for their mothers, such as with Orin Scrivello, or other female relatives or lovers). The level of misogyny can vary from a sexist attitude to outright murder (or even cause some serial killing). It is also not uncommon for them to be perverts, rapists, pimps, etc.

Although associated mainly with males, some females can be misogynists as well (examples being Jane Tiptree, Femme Fatale, Giffany, Frill, Stitch Sisters, Mrs. Carmody, Frau Engel and Sharon Quinzel).

The opposing counterpart of misogyny is misandry, the hatred of men. See Misandrists for more details on that-although the two can overlap, even if rarely (e.g. Billy Blim, Madame Amberly and Amber Canardo).

Important note: A villain who hurts females for reasons that are unrelated to gender do not count as misogynists. For example, Ganondorf repeatedly kidnaps Zelda, but comes from a matriarchal society and frequently works with female villains such as his surrogate mothers, Twinrova, not to mention that he mainly kidnaps Zelda to obtain the Triforce. Thus Ganon should not go under this category as he does not show hatred or patronizing behavior towards females as a whole.

Good examples of Misogynists include Andy Evans, Ken Wheatley, Sunny Jim, Douma, Water Street Butcher, Dan Tae Joo, Gaku Yashiro, Captain Vidal, Jabba the Hutt, Lord Piggot-Dunceby, Glenn Quagmire, Sir Piers Pomfrey, Homelander, Josh, and Hugo Martinez.