Villains from Disney's Sensational Six (also known as "Mickey Mouse and Co.") franchise: villains that have opposed Mickey Mouse, Minnie Mouse, Donald Duck, Daisy Duck, Goofy, Pluto, or all six. This also includes recurring friends and allies such as Chip, Dale, Clarabelle Cow, Horace Horsecollar, Clara Cluck, Hewey, Dewey, Louie, and any other characters in the '"Mickey Mouse" universe. This includes cartoons, comics, Disney parks, video games, television shows, and internet shows.

This also includes villains from the "Duckverse" (i.e. DuckTales, Darkwing Duck, The Mighty Ducks), as well as crossover villains such as in House of Mouse, Bonkers, and Kingdom Hearts.