While he was a magistrate of Zhongmou, Chen Gong rescued Cao Cao, who was then a fugitive, by releasing him and leaving his post to join him. However, after Cao Cao reveals his true nature to him, "I prefer to betray the world, rather than let the world betray me!", Chen Gong leaves him.
He later tries to dissuade Cao Cao from attacking Tao Qian but fails and will instead offer his services to Zhang Miao.
That's when he meeting Lu Bu and eventually becomes his advisor. It is partly because of his good advice that Lu Bu conquers the most of Yan's province by defeating Cao Cao.
However, not always listening to his advice, while he alongside with Lu Bu and Zhang Liao is defeated and captured in Xiapi. Chen Gong and Lu Bu refuses to submit and is put to death under Cao Cao.
Chen Gong is a collected and perceptive intellectual. While he is often portrayed as the voice of reason within Lu Bu's ranks, primarily concerned with the success of the army's campaigns over personal vendettas. For it would shown his loyalty to Lu Bu is unquestionable, even if he may be exasperated by his lord's recklessness. The recent titles imply that he has a strong sense of justice and morality.
- Chen Gong appears as one of the playable characters in the Dynasty Warriors series.
- Deconstructed on the historical route, where his and Lu Bu's differences in personality create a hostile situation where Lu Bu refuses to listen to Chen Gong's strategic and political advice, and Chen Gong gets so fed up with Lu Bu's arrogance and incompetence outside the narrow tactical sphere that he stops trying to talk to him. It leads to defeat after defeat, only deepening the chasm between them until each one dies insulting the other.