In the original game, he was voiced by John Doman, who also voiced Caesar.
Morello was born on December 31, 1877, in either Lost Heaven or Sicily. At some point, Morello became a close friend of Don Salieri and both served as Don Peppone's two most trusted caporegimes. However, about 43 years later in 1921, Don Peppone was killed in a deal gone awry and Morello and Salieri blamed each other for the death of the Don. They decided to split Lost Heaven into two sections: while Morello operated in the East Side of Lost Heaven, Salieri operated in Little Italy.
Mafia: The City of Lost Heaven
Morello eventually became the most powerful mobster in the city, greatly helped by his brother Sergio Morello Jr. and his connection to the city's councilor. He broke the truce he had with Salieri by expanding on Salieri's territory and thus, causing a bloody gang war between the two families. After Tommy Angelo killed Sergio on orders from Salieri, Morello's situation started to go to hell, with him destroying almost everything he owned with his overly brutal ways.
Morello's mob was eventually overwhelmed by Salieri's, and three hitmen: Sam, Tommy and Paulie were sent to assassinate him during the Othello opera play. The play ended earlier than expected, and Morello escaped the house in his bulletproof car and attempted to escape by plane and skip town. The three hitmen then chased him and eventually shot down his plane, killing him.