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|“||My research will change the face of everything!||„|
|~ Dr. Sam Isaacs proclaiming his intent on achieving his goals for the Umbrella Corporation.|
Dr. Samuel "Sam" Isaacs was a major antagonist in the Resident Evil film series, appearing as the overarching antagonist in the 2004 film Resident Evil: Apocalypse, the main antagonist in the 2007 film Resident Evil: Extinction and a posthumous antagonist in the 2016 film Resident Evil: The Final Chapter.
He was a high-ranking employee of the Umbrella Corporation who became in charge of the Nemesis Program before later serving as Head of the Umbrella Science Division, which specializes in researching methods to domesticate the infected individuals into a working and military force for Umbrella. It transpired that Sam Issacs collaborated with the Global T-Virus Outbreak to the point where he blames his superior Major Timothy Cain for causing the abrupt circumstances behind it, as as Major Cain was the one who ordered The Hive to be re-opened against Issacs' consent. It is later revealed that Sam Issacs is actually a clone of Umbrella's supreme leader, Dr. Alexander Isaacs.
He is portrayed by Iain Glen, who also portrayed Dr. Alexander Isaacs and his other clone in the series' final instalment Resident Evil: The Final Chapter - as well as Manfred Powell in the 2001 film Lara Croft: Tomb Raider.
Dr. Sam Isaacs was employed by the Umbrella Corporation sometime before the Raccoon City Outbreak. He greatly disliked his immediate superior Major Timothy Cain, a feeling that Cain returned. Isaacs blamed Cain for the Global T-Virus Outbreak, as Major Cain was the person who ordered The Hive to be re-opened to begin with.
Raccoon City Outbreak
In the follow-up of the disaster in The Hive, it was Isaacs who - at Cain's direction - experimented on Alice and Matt Addison afterwards. But disaster struck when Cain unwisely chose to re-open the Hive, despite the containment procedures. This caused numerous Zombies and Lickers to escape the facility, and the T-Virus overran Raccoon City with Alice and Addison - now subjects in the Nemesis program - still inside.
Following the bombing of Raccoon City, Isaacs was distraught to learn that both Alice and Addison were dead. But he was able to recover Alice's body from the wreckage of the helicopter she used to escape, and moved her and his work to an Umbrella facility in Detroit. After three weeks of experiments, Alice was revived with incredible new powers. Unfortunately, she retained her memories and escaped, being rescued by Jill Valentine, Carlos Olivera, and Lloyd Jefferson Wayne. But Isaacs had one last trick up his sleeve, and as Alice makes her escape, he activates "Project: Alice".
Global T-Virus Outbreak
Umbrella soon had bigger problems than one escaped experiment, however. It was soon discovered that the T-virus had escaped Raccoon City, and began spreading rapidly. The world was overrun in short order, the only survivors being the civilians who stayed on the road, and Umbrella Corporation employees, who took shelter in underground facilities across the planet. Isaacs himself took charge of the research in an underground lab in the Nevada desert, trying vainly to track Alice across the wasteland that North America had become over the last five years. All the while, he maintained a combative relationship with Umbrella Chairman Albert Wesker.
Isaacs, who had begun a cloning program to recreate Alice, attempted to use the clones ' blood to "domesticate" the zombies, making them tame enough to allow humans to return to the surface. This was possible because, as he discovered, while the zombies hungered for human flesh, they derived no actual sustenance from it, and could remain active for decades or more. The results did succeed in raising the intelligence of the test subjects, but resulted in a stronger infection.
Finally realizing that only the real Alice could bring him success, Isaacs falsified orders from Wesker and took a strike team into the wastes to deactivate and retrieve her. He made camp in the ruins of Las Vegas, setting a trap with the Enhanced Zombies to kill her so they could retrieve her corpse and take a sample of her blood.
Mutation and Death
The scheme did not go as he had planned. Alice massacred the strike team with incredible speed. After an unsuccessful attempt at deactivating her, Isaacs was bitten by an Enhanced Zombie. He returned to the lab and was placed under house arrest. He injected himself with large quantities of the Anti-virus, but his condition continued to deteriorate.
Wesker, meanwhile, had enough and ordered Isaacs' superior Alexander Slater to eliminate him. sLATER carried out the order, shooting the scientist in the heart and leaving him for dead. However, it was too late, as Isaacs had already begun to mutate, transforming into a grotesque, tentacled monster who then proceeded to slaughter everyone in the facility, beginning with Slater. Taking action, the facility's AI, the White Queen sealed him in the lower levels.
Sometime later, Alice entered the facility, and after consulting with the White Queen, descended into the lower levels to kill the mutated Isaacs. They fought in a replica of the Arklay mansion, their fight eventually moving into the reconstructed "Laser Room."
Isaacs taunted Alice, telling her that she was not the future as he had previously thought, saying "I am the future." Alice responded by saying "No, you're just another asshole.", and that they were both going to die down there. As Isaacs moved in for the kill, the laser grid activated, controlled by a newly-awakened Alice clone, and sliced him into cubes, putting an end to the deranged scientist once and for all.
Sam Isaacs was a tall, middle-aged Caucasian man of British background. He had sea-green eyes, and dark blonde hair, much like the original Alexander Isaacs.
Dr. Sam Isaacs was a man of cool temperament, being knowledgeable and rational. After the Global t-virus outbreak, he worked for the good of mankind under Umbrella chairman Albert Wesker, trying to locate Alice and take a sample of her blood, thus creating a more effective cure to the T-Virus. His methods were unorthodox, however, and he regarded his work with a higher priority than the lives of his colleagues or a few civilians. In fact, one might go as far as to call Isaacs selfish, cowardly, and cruel.
This is evidenced by the fact that after the initial test of his serum designed to domesticate zombies failed, and the zombie went berserk, killing a scientist. Sam Isaacs quickly slipped out of the room, locking the doors and sealing a second scientist inside. That scientist could have easily escaped, had Isaacs quickly let him slip out while the enraged zombie was preoccupied feasting on the first. However, Isaacs coldly watched as the man was ripped apart and eaten alive by the zombie, coolly running his fingers through his hair and adjusting his tie. His instincts for self-preservation also showed itself during the ambush in Las Vegas, when Alice attacked the Umbrella tent. Isaacs quickly fled to the nearby helicopter, leaving his colleagues to die. Isaacs maintained a wary relationship with his superior Alexander Slater, who did not much like the scientist to the point where he told him to "Just die!" when being ordered to kill him for his failure.
- Isaacs is named after actor Jason Isaacs who portrayed William Birkin from the first Resident Evil film and was created to fulfill Birkin's role in the sequel.
- Isaacs mutation is reminiscent of the T-002 from Resident Evil.