The Escalator Girls are a gang of mean girls that hang out at the escalator near The Big Squeeze. They steal from and bully people that invade "their territory." Some of their many enemies are Jude, Jen, and Nikki.
In the episode "Dirty Work", they stole Jen's house keys and Jude's skateboard and refused to give them back. When Caitlin paid Jonesy to tell them that Jen was a champion kickboxer who had killed someone in a fight, they handed over the stolen stuff as soon as Jen angrily demanded it. In the same episode, Caitlin had bought a container of new makeup called SmashFace that caused her face to darken and break out in zits. Jen tried to get her to give it up, but Caitlin foolishly refused to give it up, claiming that it was "too expensive to throw out". At the end of the episode, Nikki threw the makeup toward the Escalator Girls, who promptly tried it on and achieved the same disastrous results as Tricia Holmes and Caitlin. Without the makeup, Caitlin's complexion returned to normal, while the Escalator Girls became mocked for their hideous faces.
In the episode "Kylie Smilie", they pick on Jude by giving him a wedgie, pantsing Jude and tying knots in his clothes and putting a rose in his mouth, and literally tying Jude's arms and legs altogether. Nikki insults them and the Escalator Girls throw Nikki in a trash bin and the infuriated Nikki declares war. Jude distracts the Escalator Girls while Nikki gives each of them a wedgie. Ron the Rent-a-Cop then banned the girls from the mall.