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"Four Horsemen" may be referring to two or more different villains. If you're uncertain which one you're looking for, just flip a coin.
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And they were given authority over a fourth of the Earth, to kill by sword, by famine, by plague, and by the beasts of the earth.
~ Revelation 6:8, which tells of the coming of the Four Horsemen.

The Four Horsemen of the Apocalypse, often simply referred to as the Four Horsemen, are something of a stock character found in fiction. They first appear in the Book of Revelation in the Bible as harbingers of the Last Judgment. They have since often been used in the same manner in fiction, as harbingers for some sort of cataclysmic event (particularly in biblical fictional works.)