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De Santis. Of course I'm alone. Hard to say, he's been behaving more and more erratic.
~ De Santis calling her superiors about Caruso.

Dr. Francesca De Santis is a supporting antagonist in HITMAN (2016), appearing as the secondary target of the latter's second story mission "World of Tomorrow".

She is a well-known Italian scientist, a leading researcher at the Ether Corporation, and a Providence operative. She was assigned to make sure that Silvio Caruso finished working on the biological weapon, and was later assassinated by Agent 47.

She was voiced by Salli Saffioti, who also voiced Cleo de Nile in Monster High, Mistral in Metal Gear Solid: Revengenace and Eramis, Kell of Darkness in Destiny 2: Beyond Light.

Biography

De Santis grew up in suburban Florence as the daughter of a neo-classical composer and a stage designer. She pursued a scientific career and quickly gained reputation for her thoroughness and single-minded perseverance.

De Santis agreed to go undercover at Silvio Caruso's field lab to spy on him. She did this in order to reach the coveted position as regional head of R&D at one of the world's largest pharmaceutical companies, the Ether Corporation. She was instructed to have Caruso eliminated and carry on the work in his place, if Caruso should become a threat to the project or to the company.

Appearance

De Santis wears a lab coat over a dark dress. She wears a pendant.

Gallery

Trivia

  • De Santis is dating Caruso's golf coach, Roberto Vargas, who can be impersonated to poison De Santis.

Navigation

           SeriesLogoContracts.png Villains

International Contract Agency
Agent 47 | Diana Burnwood | Benjamin Travis | Jade Nguyen | The Saints (Jennifer Anne Paxton) | Birdie | Praetorians | Erich Soders | Agent Banner | Agent Tremain | Agent Montgomery | Agent Thames | Agent Green | Agent Rhodes | Agent Swan | Agent Lowenthal | Hush | Imogen Royce

Providence
Leadership: The Partners (Marcus Stuyvesant | Carl Ingram | Alexa Christine Carlisle)
Constants: Janus | Arthur Edwards | Diana Burnwood (undercover)
Agents: Otto Wolfgang Ort-Meyer | Silvio Caruso | Francesca De Santis | Claus Hugo Strandberg | Reza Zaydan | Erik Olander | Erich Soders | Yuki Yamazaki | Akira Nakamura | Robert Knox | Sierra Knox | Nolan Cassidy | Zoe Washington | Sophia Washington | Athena Savalas | Don Archibald Yates | Tamara Vidal | Orson Mills
Assets: IAGO (Dalia Margolis | Viktor Novikov | Nila Torvik | Owen Wagner | Scott Sarno | Kieran Hudson) | Haven (Tyson Williams | Ljudmila Vetrova | Steven Bradley)

The Franchise
Leader: Alexander Leland Cayne
Agents: Albert Fournier | Raymond Kulinsky | Angelina Mason | Mark Purayah II | Female Assassin | Maynard John | Eve | Mark Parchezzi III | Daniel Morris
Assets: Alvaro D'Alvade | Richard Delahunt | Anthony Martinez | Vaana Ketlyn

Private Militia
Leader: Lucas Grey
Members: Olivia Hall | Sean Rose | Penelope Graves | Ezra Berg | Maya Parvati | Patrick Morgan | Richard M. Foreman | Pertti Järnefelt | Alma Reynard | Orson Mills | Wazir Kale | Vanya Shah | Dawood Rangan

Main Story Targets
Original Series
Hitman: Codename 47: Five Fathers (Lee Hong | Pablo Belisario Ochoa | Frantz Fuchs | Boris Ivanovich Deruzka | Otto Wolfgang Ort-Meyer) | Odon Kovacs | No. 48s

Hitman 2: Silent Assassin: Giuseppe Guillani | Russian Generals (Rinat S. Rumyantsev) | Igor Kubasko | Masahiro Hayamoto Jr. | Masahiro Hayamoto | Brat Charliego Sidjan | Charlie Sidjan | Ahmed Zahir | Mohammad Amin | Abdul Bismillah Malik | Hannelore Von Kamprad | Deewana Ji | Agent 17 | Sergei Zavorotko

Hitman: Contracts: Campbell Sturrock | Andrei Puscus | Fabian Fuchs | Sergei Bjarkhov | Winston Beldingford | Alistair Beldingford | Rutgert Van Leuven | Arkadij Jegorov | Frantz Fuchs | Fritz Fuchs | Lee Hong | Philippe Berceuse (off-screen) | Richard Delahunt (off-screen) | Albert Fournier

Hitman: Blood Money: Joseph Clarence | Scoop | Fernando Delgado | Manuel Delgado | Alvaro D'Alvade | Richard Delahunt | Carmine DeSalvo | Rudy Menzana | Lorenzo Lombardo | Vinnie Sinistra | Mark Purayah II | Raymond Kulinsky | Angelina Mason | Lorne de Haviland | Chad Bingham Jr. | Mysterious female assassin | Gator Gang (Everett Jefferson | Skip Muldoon | Junior O’Daniel | William S. Corfitz | Adam Hendrikson | Joe Netberg | Elijah Krup | John LeBlanc | Hank Leitch Muldoon) | Sheikh Mohammad Bin Faisal Al-Khalifa | Tariq Abdul Lateef | Hendrik Schmutz | Vaana Ketlyn | Eve | Maynard John | Anthony Martinez | Mark Parchezzi III | Daniel Morris | Alexander Leland Cayne

Hitman: Absolution: Diana Burnwood (spared) | King of Chinatown | Dominic Osmond | Larry Clay | Bill Dole | Frank Owens | Edward Wade | Hope Cougars | Lenny Dexter (optional) | Marcus Green | Raymond Valentine | Warren Ashford | Sanchez | The Saints (Jennifer Anne Paxton) | Clive Skurky | Layla Stockton | Blake Dexter | Jade Nguyen | Praetorians | Benjamin Travis | Sanchez

"World of Assassination" Trilogy
HITMAN (2016): Kalvin Ritter | Jasper Knight | Viktor Novikov | Dalia Margolis | Silvio Caruso | Francesca De Santis | Reza Zaydan | Claus Hugo Strandberg | Jordan Cross | Ken Morgan | Sean Rose | Penelope Graves | Ezra Berg | Maya Parvati | Erich Soders | Yuki Yamazaki

HITMAN 2 (2018): Alma Reynard | Sierra Knox | Robert Knox | Rico Delgado | Jorge Franco | Andrea Martinez | Vanya Shah | Dawood Rangan | Wazir Kale | Janus | Nolan Cassidy | Zoe Washington | Sophia Washington | Athena Savalas | Tyson Williams | Steven Bradley | Ljudmila Vetrova

HITMAN III (2021): Carl Ingram | Marcus Stuyvesant | Alexa Christine Carlisle | ICA Agents | Hush | Imogen Royce | Don Archibald Yates | Tamara Vidal | Arthur Edwards

Elusive Targets
HITMAN (2016): Sergei Larin | Anthony L. Troutt | Adalrico Candelaria | Jonathan Smythe | Vito Đurić | Dylan Narváez | Gary Busey | Howard Moxon | Owen Wagner | Nila Torvik | Xander Haverfoek | Brendan Conner | Richard Ekwensi | Inez Ekwensi | Gabriel Santos | Etta Davis | Richard J. Magee | Wen Ts’ai | Richard M. Foreman | Walter Williams | Adeze Oijofor | Pavel Frydel | Akane Akenawa | Pertti Järnefelt | Kieran Hudson | Bartholomew Argus | Ji-Hu | Mr. Giggles

HITMAN 2 (2018): Mark Faba | Vicente Murillo | Miranda Jamison | Barbara Keating | Censor | Jimmy Chen | Legacy Elusive Targets (Ji-Hu | Owen Wagner | Adalrico Candelaria | Anthony L. Troutt | Richard J. Magee | Mr. Giggles | Bartholomew Argus | Richard M. Foreman | Brendan Conner | Vito Đurić | Walter Williams | Etta Davis | Adeze Oijofor | Xander Haverfoek | Gabriel Santos)

HITMAN III (2021): Kody Haynes | Joanne Bayswater | Terrence Chesterfield | Philo Newcombe | Jack Roe | Robert Burk | Allison Moretta | Sully Bowden | Legacy Elusive Targets (Anthony L. Troutt | Richard J. Magee | Jimmy Chen | Barbara Keating | Owen Wagner | Dylan Narváez | Mr. Giggles | Wen Ts’ai | Pertti Järnefelt | Ji-Hu)

Others
Non-Targets
Ivan Zilvanovitch | Mister X | Malcolm Sturrock | Margeaux LeBlanc | Adam "Kane" Marcus | Aleksander Kovak| Terry Norfolk | Tren Po | Sir Humphrey Titus Rutherford | Mabaya Mzabuni | Kurt Donovan | Nelle Brent | Max Decker | Isabella Caruso | Viana Buccho | Erik Olander | Dexy Barat | Thomas Cross | Benjamin Bertram | Lloyd Burgess | Katashi Ito | Akira Nakamura | Simone Larin | Whitecap | Tommy "the Hammer" Stoakes | Orson Mills | Jin Po | Sun Po | Hector Delgado | Kashmirian | Bhavin Sagar | Helen West | Frank Schmidt | Jebediah Block | Blake Nathaniel | Zachary Yates | Mateo Pérez | Fabian Mann | Gourd and Sugar Squirrel | Jason Portman | Leah Cooper | Zana Kazem | Mr. Fernsby | Zachary Carlisle | Emma Carlisle | Rolf Hirschmüller | Michael "Mishoo" Nenkpv | Sister Lei | Xu Junli | Corvo Black | Juan Cortázar | Valentina Yates

DLC Targets
Patient Zero: Liberation (Oybek Nabazov | Sister Yulduz | Craig Black | Brother Akram | Bradley Paine | Owen Cage) | Klaus Liebleid
The Sarajevo Six: Sarajevo Six (Scott Sarno | Gary Lunn | Walter Menard | John Stubbs | Patrick Morgan | Taheiji Koyama)

Bonus Mission/Special Assignment Targets
HITMAN (2016): Kong Tuo-Kwang | Matthieu Mendola | Harry Bagnato | Marv Gonif | Marco Abiatti
HITMAN 2 (2018): Dmitri Fedorov | Blair Reddington | Basil Carnaby | Ajit "AJ" Krish | Galen Vholes

Sniper Assassin Targets
Hitman: Sniper Challenge: Richard Strong Jr.
HITMAN 2 (2018): Dorian Lang | Guillaume Maison | Doris Lee | Jin Noo | Re Thak | Lhom Kwai | Roman Khabko | Vitaly Reznikov

Organizations
Ark Society | Blue Lotus Triad | CICADA | Crystal Dawn | Delgado Cartel | Franchise | Gator Gang | IAGO | Khandanyang | Liberation | Private Militia |Providence | Red Dragon Triad | Yardbirds

Novels
Hitman: Enemy Within: Puissance Treize (Ali bin Ahmed bin Saleh Al-Fulani | Pierre Douay | Louis Legard | Cassandra Murphy | Mrs. Kaberov | Tova Holm | Hans Pruter | Aristotle Thorakis)
Hitman: Damnation: Hector Corado | Dana Linder | Darren Shipley | Bruce Ashton | Charlie Wilkins

Movies
Hitman (2007): Mikhail Belicoff | Yuri Marklov | Udrei Belicoff
Hitman: Agent 47 (2015): John Smith | Antoine Le Clerq | Dr. Albert Deleriego | Fabian


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