De Santis. Of course I'm alone. Hard to say, he's been behaving more and more erratic.
~ De Santis calling her superiors about Caruso.

Dr Francesca De Santis is the secondary antagonist of "World of Tomorrow" episode of Hitman. She is a well-known Italian bio-engineer and member of Providence.


De Santis grew up in suburban Florence as the daughter of a neo-classical composer and a stage designer. She pursued a scientific career and quickly gained reputation for her thoroughness and single-minded perseverance.

De Santis agreed to go undercover at Silvio Caruso's field lab to spy on him. She did this in order to reach the coveted position as regional head of R&D at one of the world's largest pharmaceutical companies, the Ether Corporation. She was instructed to have Caruso eliminated and carry on the work in his place, if Caruso should become a threat to the project or to the company.


De Santis wears a lab coat over a dark dress. She wears a pendant.


  • De Santis is dating Caruso's golf coach, Robert Vargas. Vargas can be impersonated to poison De Santis.