He was portrayed by Josh Lucas.
Glenn Talbot is a former millitary officer-turned-bioscience executive at a company that is also a politically powerful Defense Department contractor. He is a long-lost acquaintance of Betty Ross (who knew him back when she was in college, and he was an officer under Gen. Ross' command). This Talbot is ambitious, pushy, and obsessed with making a big fortune quickly; he targets Betty and Bruce's lab for hostile takeover if they keep refusing his offers to quit the lab in order to work for his firm.
Later in the film, he becomes bent on getting a tissue sample of Hulk for military "super-soldier"-type applications. Throughout the film, his attempts to bully Banner constantly result in his being thrashed by the Hulk. Upon capturing Banner, Talbot begins the tissue extracting process, but fails when Banner manages to break free. Ross orders Talbot to come to him, in order to have a full evacuation of the underground detention center. However, Talbot ignores Ross' orders for a lockdown. Talbot is killed when he fires an explosive missile at the Hulk, and it ricochets off of the Hulk's impenetrable skin and back towards Talbot.