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The Great Leader of Destron is the leader of the criminal organization Destron and the main antagonist of Kamen Rider V3. He is the second incarnation of the original Great Leader. He remained hidden for most of the series before being revealed to be a living skeleton with a beating heart, calling himself the God of Death.
At some point, the Great Leader came across Joji Yuki, a brilliant young man as he was about to commit suicide and took him in, conditioning the young man to see him as a father figure and appointing him head of Destron's science division, making him believe that his scientific knowledge would be used for good.
After Shiro Kazami and his family took in Junko Tama, a woman fleeing from Destron, the Great Leader sent Destron Inhumanoids to kill her and Shiro's family, but Shiro and Junko managed to escape. To avenge his family's deaths, Shiro was inspired to become Kamen Rider V3 and fight against Destron.
The Great Leader initially commanded the Japanese Division directly, but after the continued failures of the Mechanical Army to defeat V3, the Great Leader summoned one of his generals to oversee the Japanese Branch. His monsters are typically a combination of a manmade object and an animal.
In the last few episodes, he appeared in person for brief periods of time, but he wore a robe with a hood which hid all of his features. In the final episode, he confronts and fights Kamen Rider V3. V3 cracks his skull open, revealing a tape player with a recorded message from the Great Leader, hinting that the skeleton encountered was just a decoy for the real Great Leader.