The Humanoise are androids who in the 2121 have conquered most of Earth and minor antagonists in Kamen Rider Zi-O.
In a future subconsciously created from Sougo Tokiwa's daydreams, the Humanoise conquered most of Earth and exterminated much of humanity, leaving several survivors within a protected area. However, humanity received unexpected help from Rento Makina, a Humanoise who defected from the Humanoise's goal of exterminating humanity and became Kamen Rider Kikai to defend the remaining humans from his own kind.
When Sougo's visited 2121, he was attacked by the Humanoise but rescued by Rento Makina. However, Rento's recharging satellite was hacked by the Humanoise, reverting him back to his original directive to destroy humanity. They also plotted to lure out humans with a fake radio broadcast but were fought off by Zi-O II. The reprogrammed Kikai was later disabled and purified by Sougo, restoring Rento to being a defender of humanity.