Isis is the Egyptian goddess of love and the underworld in the CW Television series Smallville. She served as the main antagonist in the episode "Isis" of the Tenth and final season.
Isis ruled Egypt as an immortal pagan goddess alongside Osiris, god of death, and were married. Once she marched towards the ends of the earth to help him. During her reign, she somehow brought the great god Ra to his knees. Her husband was later murdered by his brother Set out of jealousy and was cut into a thousand pieces doomed to roam the underworld alone. She tried to resurrect him by collecting all the pieces, but failed to find his heart. She was then trapped in an amulet by Set for centuries. It was later said the amulet was cursed and whoever possessed it was doomed to spend eternity in the underworld.
When Lois Lane traveled to Egypt on assignment, she enters a huge pavilion tent, filled with books, ancient archeological artifacts, including the medallion of Isis. After examining the long beaded necklace of Isis, it accidentally fell into her bag and Lois took it back by mistake to Metropolis. Oliver planned to throw an Egyptian gala at the Metropolis Museum when he was informed that the amulet of Isis was missing from the show's pieces. Lois dressed for the party in a costume and took her bag unaware that she had accidentally packed the amulet in it. She heads to the Daily Planet 's roof waiting for Clark to talk to her. While looking for her lucky lipstick, Lois was shocked to find the missing amulet instead. When she held it up to the sun, she is subsequently possessed by the spirit of Isis. Clark then arrives and tells the person whom he thinks is Lois that he was the Blur; to which she responds that the news was unimportant to her. While Clark is stunned, Isis/Lois suddenly flies away after declaring that she is now Isis.
Isis went to the Metropolis museum by ripping open a metal door and heads towards a crate containing Osiris’ heart ripping off the lid.