Isis Vanderchill is the villainess in the episode "All's Fahrenheit in Love and War" from Darkwing Duck.
Isis was the owner of the Vanderchill Ice Factory, which obviously produced ice. Being obssessed with her beauty, she decided to through a surgery to freeze her face in order to prevent the effects of aging, but the surgery failed, freezing her blood instead. While this incidente gave her ice-based powers, she suffered from inescapable cold as a side effect.
She started residing in an underground cave near the planet's magma to warm herself, but that wasn't enough, so she employed a gang of fireflies to melt all the gold of St. Cannard, which she would then use to coat the entire city in order to reflect the sunlight and heaten the entire city, thus giving her the warmth she so desired. Darkwing found her cave while giving chase to the fireflies, but she felt in love with him and decided to take him to a date. Launchpad eventually found out her plan, forcing her to lock up the two while she proceeded with the plan. Darkwing defeated her by turning her ice machine against her, freezing her solid. She is then taken under arrest, never to appear again.