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Isshiki Ōtsutsuki is the main antagonist of Boruto: Naruto Next Generations. He is an Ōtsutsuki clan member who have been in possession of Jigen and have been using Jigen's name as his own. He is the leader of the Kara organization. According to Sasuke and Amado, Isshiki was paired with Kaguya Ōtsutsuki when they arrived on Earth. However, Kaguya betrayed Isshiki leaving him to take possession of Jigen.

Personality

Isshiki is a cruel, ruthless and pragmatic being, having completely overtook Jigen's mind and body and showing no care or respect for the body he inhabits, cursing at his limits and degrades him as a worthless vessel. Having deemed Jigen's body as weak, Isshiki strongly desires in possessing Kawaki and turning him into his new body. He had no qualms subjecting Kawaki to a brutal, harsh training so he would master Kama despite having promised him safety.

While leading Kara, Isshiki shows formality and courteousness, addressing the fellow members of his organization politely before beginning their meeting, though he can show a serious and authoritarian side to himself that can easily silence even the prideful Victor and hot-headed Delta and make them follow his orders despite any reluctance in their part. Unlike the other Otsutsuki, he seems to have a sense of comradery, referring to the other Inners as comrades and indicating he was willing to negotiate with Koji and Amado despite their betrayal costing him Kawaki, and is not above showing pity towards his foes, as he, albeit condescendingly, showed sympathy towards Koji for not realizing he was being made a fool by Amado and courteously and kindly asked for a last message for him to deliver to Amado. He even extends his manners to his enemies, as he politely greeted Naruto Uzumaki, and apologized for not removing his shoes when entering the Uzumaki household.

Unlike the other Otsutsuki and Inners, who have shown themselves to be sadistic and confrontational, Isshiki is shown to prefer diplomacy and swift handling of the problems at hand, preferring to only incapacitate enemies when not necessarily having to kill them and even willing to avoid conflict if potential adversaries are agreeable to his terms, as shown by how he merely left Naruto pinned down after he easily knocked him aside and was willing to accept Kawaki's deal of sparing Naruto if he returned willingly. Likewise, he is much more composed and systematic in his approach to matters at hand, scarcely showing anger when things go against his plans and remaining as determined and unrelenting as ever.

While fully confident in his overwhelming power to the point of slight arrogance, unlike the rest of his brethren, he is much less prone to arrogant boasts and unlikely to let his arrogance cloud his judgement, even willing to praise foes, as he merely calmly threatened to eliminate Naruto and while remaining unfazed at facing both Naruto and Sasuke, he complimented Sasuke for his intelligence and ability to see through his ability, praised their performance in revealing the weakness of his ability and despite lapsing upon using his full power and overwhelming them rather easily, frequently mocking and taunt Naruto and Sasuke for their poor efforts, he is not above admitting their strategical attempt was a good one and even stated he felt entertained by the fight and expressing bizarre gratitude before decisively defeating them. His greatest lapse was when fighting Kashin Koji, where despite his vessel being critically weakened from his defeat of Naruto and Sasuke, he remained confident he could defeat the man, which lead to Koji persisting enough to lure him into a trap that killed his vessel. He even toyed with Koji as soon as he was reincarnated to show the vast gap between their powers and took time to teach Koji the secrets of his techniques after decisively defeating them.

Due to his surprising lack of over-confidence, Isshiki is shown to be extremely intelligent, cautious and perceptive, as he keeps the full extent of his powers a secret from even his closest allies and easily sees through Kashin Koji and Amado's plans but conceals any suspicions he had regarding Kashin Koji and Amado, luring them into revealing their plans. He was even willing to admit that despite having figured out Amado's goals, the old man had managed to get the better of him.

Isshiki displays complex beliefs regarding fate and shinobi: He believes that all living beings have their fates predestined by their genetics, stating that Koji, a clone of Jiraiya, is destined to die just like his template due to having inherited his genes despite acknowledging his fate to be that of a mighty star of change, which indicated that he may have respected the man's fate. Unlike his brethren, Isshiki seemed to have an unusually higher view of them, believing them to be above that of the self-sacrificing pawn he saw Koji to be, and he later on said that due to Koji being unwilling to acknowledge Amado's betrayal, he had the weaknesses of a normal human and was not fully a professional shinobi, suggesting that though his description of Naruto as a peace-loving idiot and outright dismissal of the shinobi threatening his organization indicated he still saw them as being beneath him, he does acknowledge and respect them above normal non-chakra using humans and found their willingness to sacrifice themselves as being worthy of praise.

Biography

Past

Not much is known about Isshiki's past, but he was paired with Kaguya Ōtsutsuki and they arrived on Earth. Kaguya, some point after eating the Chakra Fruit, apparently seeing Isshiki as too much of a threat, caught him off-guard and mortally wounded him. On the verge of death, Isshiki was forced to enter Jigen's body via his ability to shrink himself, entering Jigen's body via his ear and taking control of it and branding him with his Kama. However, Jigen was too weak and would die even if he were to resurrect and as such he chose to not reincarnate using his body.

Jigen trying get his vessel

Jigen trying to the find the next vessel.

At some point, he founded Kara and while controlling Jigen's body, became the leader, with the goal of collecting the Chakra Fruit by cultivating a new God Tree huge enough to devour all life on Earth, which all the Inners were apparently attracted to and thus why they joined him. Seeking to find a new vessel, Isshiki adopted Kawaki from an abusive father by buying him off for himself and introduced himself to Kawaki as his new father and told him to make himself at ease. After buying several more boys, Isshiki and Amado attempted to pass on his Kama to create his new vessel. All the boys died from the painful process but Kawaki survived and as a result became Kara's vessel. Isshiki took Kawaki in as his student and brutally trained and sparred with him repeatedly in order to master Kama and also become a warrior, clearly having always won with no effort while dramatically holding back, and would also at times physically beat Kawaki whenever he complained about the pain of Kama, as he saw it as being a weakness and Kama as proof of Kawaki's identity as his adopted son and vessel of Kara. Isshiki expressed relief whenever Kawaki showed anger and noted that the reason why he gave Kawaki Kama was because he was, in his eyes at least, empty with nothing in him, be it family, friends, talent, and power, with not even a single one of those things being in his possession and therefore he gave him the special seal to fill the hole inside him. Kawaki complained about the pain, but Jigen would get angry and continue to beat him. Although the Inners also participated in Kawaki's training, Isshiki ultimately remained the most active on the training of his adopted son and invested a great deal of money into Kawaki's development, enough to buy an entire country, and one of the known experiments he did was having Amado extensively modify Kawaki to the level of reaching his circulatory and nervous systems with microscopic Scientific Ninja Tools, possibly courtesy due to his ability to shrink objects. He apparently did not limit his training of Kawaki to just simple mastery of melee combat and the usage of his powers, also granting Kawaki some insight on the Shinobi world, as the latter stated he was granted access to Kara's files, allowing his adopted son knowledge on the Shinobi Villages and Tailed Beasts.

Kawaki Arc

Kara meeting

Jigen meeting with Kara.

Isshiki eventually put Amado in charge of Kawaki but Amado, having intended to stop Isshiki and the entire Otsutsuki Clan out of disgust, purposefully let Kawaki escaped along with Koji Kashin by downing the airship carrying Kawaki. Isshiki, however, was not fooled and knew it was them: He just didn't knew their motives. Instead of retrieving him as he easily could, Isshiki, wanting to know the true reasons of Amado and Koji's mutiny, decided to bait them and activates his Genjutsu Communication technique to summon all the other inner members of Kara where he reveals that the vessel has escaped and after agreeing with Koji that it was the half-hearted calculation used by an elderly member of Kara that caused all this, coldly tells said member that the plan he has regarding Armado has nothing to do with him. He agrees instantly to sent in Koji to retrieve the vessel, desiring to let him loose so he can figure out his true intentions, and before dispelling the Genjutsu, makes the priority of the mission clear, authorizing any and all methods as long as the vessel is retrieved.

Jigen and Delta

Jigen dining with Delta.

A few days after talking with members of the group about retrieving the vessel, Isshiki, while dining with Delta, gave her permission to go with Koji to look for the vessel but made it clear her role is only to report to him if there were problems regarding Koji's work and she will submit to whatever Koji planned, not wanting Delta to ruin his plans of figuring out Koji's intentions. As Delta leaves, Isshiki finishes his meal in silence as he contemplates the events happening.

After Delta's failure at attempting to retrieve the vessel, having been decisively defeated by Naruto, the Seventh Hokage, while Kashin Koji merely watched far-away and realized from the battle Isshiki's strength even with him limited still surpasses Naruto's own terrifying power, and subsequent tantrum with the other Inners, Isshiki sternly calms down Delta and reminds her that it is Koji Kashin's job to retrieve the vessel. Delta tells him that Koji Kashin have not been doing his job right to retrieve the vessel as he allowed the Leaf Ninjas to take the vessel away and he remains at the Hidden Leaf Village to gather information. Curious, Isshiki asks Delta what information and Delta tells Isshiki that Boruto Uzumaki has a kama seal. Smirking at the new information he heard from her, Isshiki happily thinks about Momoshiki Ōtsutsuki and his involvement in giving Boruto the kama seal and seeing Boruto's kama as being a fortune as it would extend Kara's time limit and efficiency made him desire Boruto too. With Naruto's guarding of Kawaki, Isshiki, knowing better than to send in other members of Kara despite Code's bravado that he and Boro could retrieve Kawaki, decided to personally retrieve his adopted son and also acquire Boruto.

Jigen and Ten Tails

Jigen meets with the Ten-Tails in an unknown location.

Anticipating the possibility of being cornered in his incoming attack on Konoha and attempt to retrieve Kawaki and Boruto, Isshiki uses his space-time ninjutsu to teleport to an area that has information on the Ōtsutsuki clan to absorb the power of a creature he calls the Ten-Tails as Sasuke, who had arrived earlier, watch from above the pedestal. The Ten-Tails attempts to eat his vessel but he tells it that he is not ready for that because he has not completed the vessel. In order to strengthen Jigen's body so it would not be so easily overwhelmed, he absorbs chakra from the Ten-Tails with his Kama to the point that he sprouts his true form's horn briefly, greatly unnerving Sasuke, who retreated to warn Naruto. After gaining a significant amount of chakra, Isshiki muses on his impending assault on Konoha.

Jigen confronts Kawaki

Jigen confronts Kawaki at Naruto's house.

Isshiki forcibly activates Kawaki's kama seal and has it open a portal for him to enter Konoha through, his power instantly being sensed by Yamanaka Ino, who fearfully analyzes his chakra as being incredibly sinister and mobilizes the Police Force as backup. The first thing Isshiki saw was Koji Kashin's frog that he used to watch Kawaki and Boruto and Koji immediately un-summoned it as he looked suspiciously before focusing on Kawaki. He notices the surroundings as the Uzumaki house and politely apologizes to Naruto for having his shoes on only to be coldly rebuffed by the Hokage, who challenged him to battle. Unfazed, Isshiki says that he only wants to retrieve Kawaki and when Naruto attempts to intervene between Ishiki and Kawaki, Jigen immobilizes Naruto with his chakra rods that depletes him of his chakra.

He proceeds to easily immobilize Kawaki with a tight grip on his Kama arm and is exasperated by Kawaki's preference of artificial right-hand replacement over Kama. Isshiki proceeds to ridicule it as unsightly and that the village were using it to monitor him, making it no different to the kama seal, and as Kawaki rebuffs him, Isshiki merely twists Kawaki's hand and tries to persuade Kawaki into seeing the Leaf Village as a place that does not care about him and only wants him as a bait and Naruto as nothing but a peace-obsessed idiotic coward so that Kawaki can return to the Kara base. Kawaki resists Isshiki's persuasion and tells him not to disrespect the Seventh Hokage. The kama seal grows around Kawaki altering his appearance by making him grow a horn on the side of his head to Isshiki's surprise as he didn't expect Kawaki to develop so rapidly. Naruto kicks away Isshiki and seeing Naruto won't stop interfering, Isshiki activated Kama and expressed his intent to kill Naruto. As Kawaki offers himself up to Isshiki in exchange for him not fighting Naruto, fearing what Jigen's far superior power to Delta could do to Naruto, Isshiki calmly accepts the deal as long as he remains cooperative but Naruto refuses to.

Jigen fights Naruto and Sasuke

Jigen fights Naruto and Sasuke.

Seeing no compromise, he warps himself and Naruto to his personal dimension, intending to strand him there, but is sucker kicked by Sasuke, who follows Naruto's chakra there. Isshiki muses on his poor timing, stating that if he had arrived later, he could have brought back Naruto without a futile battle, and laughs when Naruto and Sasuke instead declare the terrain allows them to fight freely against him. Despite his opponent's bravado, even when limiting his vessel's power, Isshiki quickly proved to be a mighty foe, as he effectively either repelled or shrugged off their blows and landed black rods on them completely unnoticed. However, after they had learned of the true nature of his abilities, Isshiki was only able to stalemate them and after escaping unscathed, realizing his foes are too powerful, he compliments his foes for fighting so well before finally completely releasing his power, progressing Jigen's Kama to the point of sprouting his horn.

Isshiki is then angrily shocked when Sasuke reveals that he is aware of that power, calling him a wretch and demanding to know where he learned the location of that dimension, only for Sasuke and Naruto to ignore the question and activate their full power. Unfazed, he soon gains the upper hand decisively on them, breaking even their mighty avatar forms of Susanoo and Kurama with ease and soon having them on their knees all with simple physical attacks and large rods. However, while easily dominant, in fact, his opponents still held on enough to make him use way too much chakra and the blackened section of his body cracks. Isshiki comments that Jigen's body cannot fully keep pace with his power and unable to prolong the battle anymore else he would completely break apart, he restrains both Naruto and Sasuke with black rods impaling them, badly injuring them. Although able to kill Naruto, Isshiki decides against it, both as he wouldn't want to waste the chakra needed and seemingly because he wants to use Kawaki to force Naruto to cooperate, but he still easily has the power to kill Sasuke, but fails as Sasuke warps away.

Isshiki then prepares to seal Naruto along with the Nine-Tails away. As Naruto tries to insult Isshiki, the Nine-Tails advises him to not provoke him any further and that it is better that he is sparing his life for the moment. Isshiki agrees with the Nine-Tails stating that he has no issue with Naruto and targets Boruto but seemingly warning him that once he recovers, he will use him as a bargaining chip for Kawaki, tells him that should he try to fight him again, apparently calculating the possibility of Naruto trying to rescue Kawaki upon him capturing back his adopted son, it will be his end and tells him to enjoy the dark surroundings he is now trapped in, musing that at least he doesn't have to be busy anymore. Isshiki then sealed both Naruto and the Nine-Tails away. Afterwards, Jigen's body collapses and even begins to tear up from the amount of pain his body is going through. Isshiki curses at Jigen's inability to use his full power for long and teleports away.

Returning to the Kara base, Isshiki, critically weakened from the battle, is treated by Amado who rebukes him for using too much power with Jigen's body, noting that it would take 2 days to return to full power as his chakra is almost zero. Isshiki, unconcerned, happily thinks about Kawaki and how much he has progressed as the vessel, proud of his adopted son's growth. He remarks on Kawaki and Boruto's progress stating that they will soon become Ōtsutsukis with the power that they have and ensures Amado all of Kara will be rewarded just as he has promised.

He is soon confronted by Koji Kashin, who attacks him in order to force him to reincarnate in Jigen's body. Despite easily handling Koji's attacks for the most part, Isshiki in his weakened state was eventually caught and trapped in great flames from burning mountains. Jigen's body killed, Isshiki was forced to reincarnate in Jigen's body.

Now at full power, he began to randomly shrink objects he caught sight of, forcing Koji to retreat, before he soon caught Koji's mask in sight and shrunk it to the point of destroying it. With his Byakugan active, Isshiki saw that Koji was a clone of Jiraiya and that Amado held his fate as being mighty and wanted to use it to perhaps change the outcome but states that Koji will still die just as his genetic template did as every genes have a predestined fate that cannot be opposed.

Effortlessly diminishing all of Koji's flame assaults, his powers now having increased to a completely different level than his already tremendous might while possessing Jigen, Isshiki even toyed with him by simply shrinking himself to Koji's shoulder to dodge his hair-manipulating jutsu and saying he could use all his power and still never able to defeat him. Casually dodging Koji turning his hair into needles, Isshiki commented on how tremendous his powers are but also revealed that Jigen's body would die in 2-3 days due to being unable to withstand it and cursed Amado as he had lost Kawaki's Kama but ridiculed Koji for still not understanding that Amado had been using him all along and had never intended him to survive the battle, knowing fully well only the Hokage and Sasuke can possibly defeat him, correctly knowing Amado sought refuge in Konoha, and derided him for believing himself to be a shinobi while in truth he was a mere sacrificial pawn. Seeing Koji enter Sage Mode, Isshiki continued to attack Koji, casually handling his fiery assaults and overpowering him in hand-to-hand combat as he derided Koji for continuously using Fire Release and nothing else, calling him lame. When Koji revealed he was luring Jigen into a trap to use his Ultra Big Ball Rasengan, Isshiki activated his dojutsu to use Daikokuten, summoning the pillars he had earlier shrunk to pin down Koji, decisively defeating him.

Manifesting his original clothes and a wine bottle to explain his Daikokuten technique, Isshiki continued to ridicule Koji for believing that he is an actual shinobi as he lacked the professionalism and for all his bravery and pride to stand against him even though knowing he would die, he has the weaknesses of a normal human. Isshiki then acknowledged that Amado had managed to get the better of him but is unconcerned and vows to kill him for it and asks Koji for his last words so he can tell Amado about it. Koji merely responded by summoning a toad and reverse summoning it to escape but Isshiki couldn't care less about pursuing Koji, Kawaki being his main target, and teleported to Konoha, levitating ominously above the village.

Powers and Abilities

Isshiki is currently the most powerful being in the entire Naruto series, even surpassing the might of Kaguya Ōtsutsuki herself, who could only defeat Isshiki due to catching him off-guard. Even while only possessing the body of Jigen, which considerably limited his power, as Isshiki's power is so great that unleashing the full extent of his power via the Kama he gave Jigen was enough to overwhelm his body with his immense chakra and cause it to break down, he is still the supreme leader of the extremely powerful organization Kara, feared and respected by all of it's members, even far surpassing the other completely monstrous Inners, as shown when he easily intimidated Delta and Victor, with Kawaki stating he is on a completely different level compared to Delta, and Kashin Koji, who had easily killed Victor, and Amado would not dare face him until his vessel was severely weakened from his battle with Naruto and Sasuke, who he could not only pressure while still limiting himself, but once going all-out, he was able to decisively defeat two of the strongest shinobi in history. Amado stated that Isshiki possessed enough power to destroy the world if he were to return to full strength and stated even while imperfectly reincarnated, Isshiki still had the power to destroy Konoha in a rampage.

Physical Prowess

Isshiki is shown to be a very resilient man, able to survive being bisected long enough to find a new host. While possessing Jigen, Isshiki displayed incredible prowess in close-quarters combat, both with weapons and unarmed. Even without having Jigen's body access more of his power, he shows tremendous speed and strength, easily kicking Naruto away, impressing the Hokage with his reaction, and effortlessly catching a punch from Kawaki when he had Kāma activated, causing Kawaki visible pain by merely lightly twisting his arm. He is also highly durable, suffering no injuries from a direct kick from Naruto in his Six Paths Sage Mode and even while severely weakened from his battle with Naruto and Sasuke, he could easily pressure Kashin Koji without even using his greater power levels. Isshiki has also displayed remarkable proficiency with a large black rod to easily parry blows from Sasuke, despite his skill in kenjutsu.

While using Kāma to a limited level, Isshiki proved to be more than a match for Naruto's Six Paths Sage Mode, able to easily handle his attack and pressure him and would have defeated him had Sasuke not came to his aid. He also took no damage from Sasuke's attack and was able to swiftly react to his continued assault and even deflect his surprise attack. Upon fully using his power, Isshiki displays such a tremendous level of physical strength and speed that he was able to effortlessly dodge Sasuke's Complete Body Susanoo and Naruto's Tailed Beast Mode attacks and plunge them out with a single attack as well as pummel them severely with just a few punches and kicks. He is also resilient enough to be completely unfazed by being burned by Amaterasu, which could harm even Tailed Beasts, proceeding to calmly absorb it. After being fully reincarnated, Isshiki was able to quickly overpower Koji using Sage Mode in terms of strength and withstand being burned by his flames unfazed to shrink it.

Chakra

Isshiki wields tremendously powerful chakra, so vast and powerful that his full power is capable of overwhelming Jigen's body with the sheer intensity of it and reincarnating himself in Jigen's body would kill it in a few days. Even while limiting himself, his sinister chakra was already strong enough to terrify Ino Yamanaka to the point of near-collapse and was compared by Kawaki to Naruto's Six Paths Sage Mode. When unleashing more of his power through Jigen's Kāma, his chakra was such that it intimidated Sasuke into fleeing and later on unnerved both him and Naruto. He appears to suffer no strain from using his high-level Genjutsu Communication to connect with the other Inners of Kara for prolonged periods of time even in Jigen's body and likewise has no trouble performing Space Time Ninjutsu liberally, even though even for other Otsutsuki such abilities can be taxing.

Ninjutsu

Isshiki is capable of making use of black rods to an even more lethal degree than the Otsutsuki and other Rinnengan users: In addition to his rods being able to uniquely drain chakra, upon using more of his power, Isshiki can instantly summon them so fast that both Sasuke and Naruto weren't able to react to it and even form them from his neck to defend himself from Sasuke's attack. He shares the trademark Otsutsuki ability of levitation, chakra absorption and space-time ninjutsu. His chakra absorption can absorb large amounts of chakra from his Ten Tails and easily deal with techniques like Naruto's Rasengan and Amaterasu, being unaffected even when shrunk. He has also displayed advanced mastery of Space-Time Ninjutsu compared to his fellow brethren, as he is able to apply it in combat, creating the black shrouds he uses to teleport fast enough to catch foes off-guard and teleport out of attacks at the last moment. In addition to being able to transport himself to Ten-Tails dimension, he has access to his own personal dimension, a world of rolling storm clouds that he can use to strand foes in. He also proves himself to be powerful in the art of Fuinjutsu, owning a sealing coffin that is powerful enough to seal Naruto firmly with no other way but space-time ninjutsu to break the seal.

Dojutsu

Isshiki has a currently unnamed right eye dojutsu that allows him to perform his signature technique Sukunahikona, a technique that allows him to instantly shrink himself or anything non-living target he sees and just as quickly restore its original size. Even while in Jigen's body and not manifesting this unique eye, he can still access this, though at a lower level but still fast enough to be invisible to even the eyes and senses of Naruto and Sasuke when he wasn't using his Sharingan, able to shrink his black rods to launch them at microscopic size into the bodies of his foes while leaving them completely unaware, before returning them to their original size to instantly inflict catastrophic injuries. He can also enlarge them whenever necessary to counter armed blows from enemies. He can also apply the ability to his own body, allowing him to disappear from sight and manoeuvre around the battlefield, as if teleporting, fast enough to catch the likes of Naruto and Sasuke off-guard, and is even still able to apply this to anything except living beings such as flames. While this requires hand motions while in Jigen's body, upon being reincarnated, with his right eye active, Isshiki was able to use this with just a gaze and it's on a completely different level, able to effortlessly minimize Koji's flames.

After shrinking a target, Isshiki can use Daikokuten to store any of his shrunken targets into a pocket dimension, which he can summon and at full size at any given time. Even in Jigen's body, he makes regular usage of this, as Isshiki would manifest replacements of destroyed furnishings and other items, like a table, food and drink, and even lit candles, while upon being fully reincarnated, he can apply this in combat at speeds beyond even the Sage Mode using Kashin Koji's ability to react, summoning the pillars he earlier shrunk to easily pin him down.

In addition, Isshiki also possessed a Byakugan, though seemingly only in his left eye and cannot access it when in a vessel. It presumably grants him the usual near 360° field of x-ray vision (with the presumed exception of a small blind spot at the upper thoracic vertebrae) and the ability to see the chakra pathway system. He is shown to be able to use it to read the minds and fates of others, as he quickly determined that Koji was the clone of Jiraiya and had the same fate as Jiraiya: a mighty star of change.

Gallery

Trivia

  • Even though Isshiki was reincarnated forcibly into Jigen when Koji killed Jigen, it is heavily implied that Isshiki successfully gives Kawaki another Kama and eventually succeeds in turning Kawaki into his new body, as after defeating Koji, he attacked Konoha, making it possible that he was the one who destroyed the Hidden Leaf Village and (apparently) kill Naruto before seemingly possessing Kawaki and trying to do the same to Boruto.
    • Although Kawaki's appearance seems to be his old one, it may be possible that Isshiki had brainwashed and possessed Kawaki and just hasn't reincarnated into him yet.
  • Since Isshiki is in the same clan as Hagoromo Ōtsutsuki, the ancestor of Naruto Uzumaki, he is one of Hagoromo's cousins and is therefore related to Naruto.
  • Isshiki is currently the strongest character in the entire Naruto series, clearly dwarfing the might of the empowered Momoshiki. It was stated that even Kaguya herself only defeated him via a surprise attack.
    • Although Kawaki has stated that all members of Kara have been modified extensively by Amado with fearsome Shinobi Ware, Isshiki, while possessing Jigen's body, never displayed any abilities related to Scientific Ninja Tools when he faced Naruto and Sasuke and fought them solely with his fighting skills and divine powers, leaving it questionable if he truly had been modified by Amado. A possible explanation is that as he was already so powerful, Isshiki was not actually modified by Amado unlike the other Inners. However, his body is still compatible with Amado's technology, as he was able to use it to pass down Kama to others, though it killed many others and only Kawaki survived, and additionally Amado is also able to restore Isshiki to full power after he was left exhausted and weakened even if it will take 2 days. When Koji and Amado were about to betray Kara, even though Amado was able to incapacitate Delta with a shutdown command, which Koji noted may work on him too, Koji did not bother to ask Amado about him being able to use it on Isshiki, further suggesting he hasn't been modified by Amado at all.

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