| "Jack" may be referring to two or more different villains. If you're uncertain which one you're looking for, just flip a coin.|
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- Jack (Jack and the Beanstalk); The titular beanstalk-climbing character of the classical fairytale Jack and the Beanstalk.
- Jack (One Piece); The main antagonist of the Zou Arc in One Piece.
- Jack (Shadow Hearts); A schizophrenic alchemist and a character in the videogame Shadow Hearts.
- Jack (The House That Jack Built); The villain protagonist in the movie The House That Jack Built.
- Jack "The Clown" Schmidt; The iconic character at Universal Studios' Halloween Horror Nights.
- Jack and Jill; Villains in the movie Puss in Boots.
- Jack Baker; A villain in Resident Evil 7: Biohazard.
- Jack Frost (disambiguation):
- Jack Hammer (disambiguation):
- Jack Hammer (Ace Attorney); A minor villain of the third case of the first Ace Attorney game, who tried to kill his would-be killer first and frame another person for it.
- Jack Hammer (Randy Cunningham: 9th Grade Ninja); A giant robot built by Willem Viceroy to kill Randy Cunningham, and the main antagonist of the Randy Cunningham: 9th Grade Ninja episode "Weinerman Up".
- Jack Merridew; The main antagonist of Lord of the Flies.
- Jack Hyde; The main antagonist in the Fifty Shades trilogy.
- Jack Mitchelson; The main villain of the 2001 comedy movie Say It Isn't So.
- Jack Rafferty; A character in Frank Miller's Sin City.
- Jack Spicer; One of the main villains in Xiaolin Showdown.
- Jack the Ripper (disambiguation):
- Jack Torrance; Protagonist villain of Stephen King's The Shining.
- Jack Vessalius; Main antagonist of Pandora Hearts.
- Jack (MOTHER); One of two antagonists of MOTHER
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