| "Karen" may be referring to two or more different villains. If you're uncertain which one you're looking for, just flip a coin.|
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Karen may refer to:
- Karen Plankton, sidekick of Plankton in SpongeBob SquarePants
- Karen 2.0, a robot that Plankton created as a new version of Karen
- Karen Jarrett, from TNA's Impact Wrestling
- Karen Colfax, a one-off villain from She-Wolf of London
- Karen Eiffel, a major antagonist in Stranger Than Fiction
- Karen Griffin, a one-off villain from Family Guy
- Karen White, a minor antagonist in Howling II: Your Sister is a Werewolf
- Karen (Johto Elite Four), a master dark-type Pokémon trainer and member of the Johto Elite Four
- Karen Knight, the former CEO of Meteor Systems in Criminal Case
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