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Bring it in, pee-pee!
~ Karen forcing Peter Griffin to smell her fart.

Karen Griffin is the main antagonist of the Family Guy episode "Peter's Sister". She is Peter Griffin's abusive sister and a wrestler who performs under the name of "Heavy Flo".

She was voiced by Kate McKinnon, who later played Kellyanne Conway in Saturday Night Live and Régine Le Haut in Leap! (originally released under the title Ballerina) in the American release.


When Karen drops in to visit for Thanksgiving, her niece Meg Griffin discovers that she treats Peter the same way that he treats her. Although amused at first, she realizes that Karen takes things too far and decides to work with Peter to even the odds. She even realized that Karen's abusive treatment is the true reason why Peter has been abusing her (due to Meg's resemblances with Karen), to which Peter sadly confirms. In other words, Karen is somewhat responsible for her brother being the man he is today.

Peter eventually stands to Karen during a boxing fight, which Meg helps out by smashing a chair onto Karen's head, putting her into a coma. Peter thanks Meg for her help, even apologizing for his treatment towards her, and they both hug each other in forgiveness.

It was later told that Karen is in a hospital still in the coma thanks to Meg's beating (as the chair Meg used to hit Karen wasn't a prop but a real one), but neither Peter nor Meg cared about this as they believe that she got what she deserved. It is likely that Karen may remain in the coma or die. 



  • In some ways, Karen is the reason why Peter Griffin is such an abusive jerk and for the way he is.


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Griffin/Pewterschmidt Family
Peter Griffin | Lois Griffin | Meg Griffin | Stewie Griffin | Brian Griffin | Francis Griffin | Karen Griffin | Carter Pewterschmidt | Patrick Pewterschmidt | Bertram

Brown-Tubbs Family
Cleveland Brown | Donna Tubbs-Brown | Rallo Tubbs

Recurring Characters
Glenn Quagmire | Ernie the Giant Chicken | Connie DiMico | Principal Shepherd | John Herbert Silverbird | James Woods | Diane Simmons | Joyce Kinney | Jesus Christ | Mr. Washee Washee | Pawtucket Pat

Guest Star Characters
Adolf Hitler | The Man in White | The Grinch | Superman | Bill Cosby | Mr. Rogers | Gloria Ironbachs | Jim Kaplan | Satan | Osama Bin Laden | Big Fat Paulie | The Don | Alexis Radcliffe | Nigel Pinchley | Eliza Pinchley | Leafers | Mass Media Murderer | Black Knight | Silas Pewterschmidt | George W. Bush | Brides of Christ | Mel Gibson | Lana Lockhart | Steve Bellows | Doug the Pimple | Joan Quagmire | Bill Clinton | Kyle | O.J. Simpson | Miley Cyrus | Deidre Jackson | Franz Gutentag | Evil Stewie | Jeffery Fecalman | Sheriff Nichols | Miss Emily | Charles Yamamoto | Penelope | Bobby Briggs | Sheldon | Mahmoud | Sonja | Car Driver | Michael Pulaski | Retep | Jamie, Karen and Becca | Liam Neeson | White Fang | Gretchen Mercer | Taylor Swift | Bat Damon | Ethnically Ambiguous Hijackers | Rob Gronkowski | Natalia | Anton | Harvey Weinstein | Donald Trump | George Townsend | Terminator Peter | Terminator Stewie | Terminator Brian | Terminator Lois | Pouncey

Star Wars Characters
Darth Stewie | Jabba the Swanson | Emperor Carter