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Bring it in, pee-pee!
~ Karen forcing Peter Griffin to smell her fart.

Karen Griffin is the main antagonist of the Family Guy episode "Peter's Sister". She is Peter Griffin's abusive sister and a wrestler who performs under the name of "Heavy Flo".

She was voiced by Kate McKinnon, who later played Kellyanne Conway in Saturday Night Live and Régine Le Haut in Leap! (originally released under the title Ballerina) in the American release.


When Karen drops in to visit for Thanksgiving, her niece Meg Griffin discovers that she treats Peter the same way that he treats her. Although amused at first, she realizes that Karen takes things too far and decides to work with Peter to even the odds. She even realized that Karen's abusive treatment is the true reason why Peter has been abusing her (due to Meg's resemblances with Karen), to which Peter sadly confirms. In other words, Karen is somewhat responsible for her brother being the man he is today.

Peter eventually stands to Karen during a boxing fight, which Meg helps out by smashing a chair onto Karen's head, putting her into a coma. Peter thanks Meg for her help, even apologizing for his treatment towards her, and they both hug each other in forgiveness.

It was later told that Karen is in a hospital still in the coma thanks to Meg's beating (as the chair Meg used to hit Karen wasn't a prop but a real one), but neither Peter nor Meg cared about this as they believe that she got what she deserved. Peter even refuses to check if he's the same blood type for a transfusion. It's likely that Karen died. 



  • In some ways, Karen is the reason why Peter Griffin is such an abusive jerk and for the way he is.


          Family Guy Logo.svg.png Villains

Griffin/Pewterschmidt Family
Peter Griffin | Lois Griffin | Meg Griffin | Stewie Griffin | Brian Griffin | Francis Griffin | Karen Griffin | Carter Pewterschmidt | Patrick Pewterschmidt | Bertram | Pouncey

Brown-Tubbs Family
Cleveland Brown | Donna Tubbs-Brown | Rallo Tubbs

Recurring Characters
Glenn Quagmire | Ernie the Giant Chicken | Connie DiMico | Principal Shepherd | John Herbert Silverbird | James Woods | Diane Simmons | Joyce Kinney | Jesus Christ | Mr. Washee Washee |

Guest Star Characters
Adolf Hitler | The Man in White | Superman | Bill Cosby | Mr. Rogers | Gloria Ironbachs | Jim Kaplan | Satan | Osama Bin Laden | Big Fat Paulie | The Don | Mr. Harrison | Nigel Pinchley | Eliza Pinchley | Charlie the Bully | Leafers | Mass Media Murderer | Black Knight | George W. Bush | Hennessy | Mel Gibson | Lana Lockhart | Jimmy Fallon | Steve Bellows | Doug the Pimple | Joan Quagmire | Bill Clinton | Kyle | Crippletron | Bob Grossbeard | New Brian | Stewie Wilkes | O.J. Simpson | Miley Cyrus | Deidre Jackson | Franz Gutentag | Evil Stewie | Jeffery Fecalman | Sheriff Nichols | Miss Emily | Charles Yamamoto | The Woodsman | Penelope | Bobby Briggs | Sheldon | Mickey Mouse | Mahmoud | Sonja | Car Driver | Michael Pulaski | Retep | Jamie, Karen and Becca | Liam Neeson | White Fang | Gretchen Mercer | Rob Gronkowski | Harvey Weinstein | Donald Trump | George Townsend | Terminator Peter | Terminator Stewie | Terminator Brian | Terminator Lois | Corona Virus | Brick Baker | Seymour | Alana Fitzgerald

Star Wars Characters
Darth Stewie | Jabba the Swanson | Emperor Carter | Ernie Fett |

Video Games
Family Guy: Back to the Multiverse
Bertram | Long John Peter Griffin | Nurses

Family Guy: The Quest for Stuff
Ernie the Giant Chicken | Stewie Griffin | Retep | Bitch Stewie & Bitch Brian | Big Pete Peter | Jigsaw | Stan Smith

See Also
The Cleveland Show Villains | American Dad! Villains