Lance DeLune is the main antagonist of the 2000 film The Ladies Man.

He is portrayed by Will Ferrell.

Lance is the leader of a group of cuckolded men called Victims of the Smiling Ass, all of whom have wives who cheated on them with Leon Phelps. Lance is determined to castrate and kill Leon for having sex with his wife, even though he is very obviously gay. When the Victims of the Smiling Ass finally catch Leon, Lance challenges him to a wrestling match. Leon gives a speech, encouraging the Victims of the Smiling Ass to give their wives more attention, ending the conflict peacefully.