Lena originated from a desolate future and was part of a small group of people who developed psychic powers in order to survive. She combined her powers with the others to travel back through time to a more peaceful era so they could prevent their bad future. However, Lena's lover, Nichol, was separated from them during their travel through time.
Discovering that the time-travel had caused them to age, Lena went with the other psychics to ask Dr. Gamo Whisky for help. Instead of actually curing them though, Dr. Gamo wiped their memories and converted them into his team of assassins.
Lena and the other Psychic Assassins eventually went to fight the 00 Cyborgs. However, she was forced to retreat when Cyborg 001 used his psychic powers to induce pain in the Psychic Assassins.
Lena and the Psychic Assassins later fought against the 00 Cyborgs again. Lena loaned Mai part of his power so she could send 009 to another era. However, Lena locked eyes with 009 right before he was teleported, causing Lena to sent with him.
Lena was initially hostile towards 009, but she eventually teamed up with him to survive. The two were later rescued by the other 00 Cyborgs with help from Mai.
When they returned to the present, Gamo sent Cain to eliminate them. Cain revealed to Lena that he had gained his memories back long before the others and that he had killed Nichol. Cain then fought 009 again and, as with their previous encounter, Cain beat down 009. However, Lena grabbed Cain and used the sync warp to transport both him and her to an unknown point in time.