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Lifty and Shifty are some of the few main cast that are continually portrayed in an antagonistic role and are one of the few Happy Tree Friends that deliberately malicious towards others.
Unlike the psychotic Flippy neither Lifty nor Shifty seem to have remorse over what they do but unlike Flippy they almost always recieve fatal retribution (while Flippy is famous for his resilience to death - though he is far from exempt from it).