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We were orphans. Little girls, all alone. Hydra gave us a home. Eight great houses. Twelve girls to a house. And in the end, the most determined... the most ambitious... the most aggressive... That girl would be the Viper. All it cost was everything. I have been married to a man I hated. I could not marry the man I loved. I betrayed him. And I was betrayed in turn. Then I was murdered. Death, welcome and well - deserved. But HYDRA, it seems, will never be done with me... To live, and die and live again.
~ Madame Viper

Ophelia Sarkissian, also known as Madame Viper, Madame Hydra, or Viper, is a villain from Marvel Comics and one of the leaders of the terrorist organization known as HYDRA. She is an enemy of Captain America, the X-Men, Spider-Woman, and the Avengers.



Main article: Madame Viper (X-Men Movies)

Madame Viper is the secondary antagonist in the 2013 live-action film The Wolverine. She was portrayed by Svetlana Khodchenkova.


Marvel Cinematic Universe

Main article: Aida

Madame Hydra appears in the live-action ABC TV series Marvel's Agents of S.H.I.E.L.D., set in the Marvel Cinematic Universe, in the Agents of HYDRA story arc in Season 4 as part of the "Framework" simulation. In the Framework alternate reality, she is the leader of HYDRA. She is portrayed by Mallory Jansen, who portrays Aida, seemingly as her alternate-reality counterpart.

X-Men: Evolution

Madame Hydra appears in the Season 4 episode "Target X" in the animated cartoon series X-Men: Evolution as the leader of HYDRA and the mastermind behind the creation of X-23. She is seemingly killed by X-23 while trying to escape from her in a hovering vehicle, with the child having placed explosives all around the interior; her fate is unknown, but she is presumed deceased.


Madame Viper is shown to be a completely aggressive, remorseless, schizophrenic, materialistic, cantankerous, egotistical, vindictive, impatient, paranoid, sadistic, brutal, mean, greedy, violent, uncaring, murderous, sociopathic, manipulative, unmerciful, iniquitous, selfish, cruel, rude, and evil woman whose lust for power and conquest rivals that of fellow Hydra leaders Red Skull and Baron Strucker. She can and will cross any moral line in the pursuit of her goals, and became one of the most wanted criminals in the world when she horribly mutated 8,000 people in Symkaria, which earned her a death sentence from that country.

Being a classic nihilist, Madame Viper is also completely intolerant of failure, and every agent who has ever failed her has been executed without delay. 

For all of her capacity for cruelty though Madame Viper is also driven, determined, cunning, and ambitious, and these traits mixed with her complete lack of redeeming qualities makes her a dangerous threat indeed.




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Captain America (1990): Red Skull | Valentina de Santis
Captain America: The First Avenger: HYDRA (Red Skull, Arnim Zola, Heinz Kruger, HYDRA Lieutenant & Velt) | Adolf Hitler | Roeder | Hutter | Schneider
Heroes United: Iron Man and Captain America: HYDRA (Red Skull & Taskmaster)
Captain America: The Winter Soldier: HYDRA/STRIKE (Alexander Pierce, Winter Soldier, Crossbones, Jack Rollins, Jasper Sitwell, Russo, Senator Stern, Arnim Zola, Wolfgang von Strucker, List, Scarlet Witch & Quicksilver) | Georges Batroc | Ferdinand Lopez | Gerald Durand
Captain America: Civil War: Helmut Zemo | Thunderbolt Ross | Winter Soldier | Scarlet Witch | HYDRA (Vasily Karpov, Josef & Winter Soldiers) | Hero Mercs (Crossbones)

           BigHero6Title Villains

Everwraith | Lord Deathstrike | Silver Samurai | X the Unknowable | Madame Viper | Badgal | Whiplash | Crimson Cowl | Yandroth | Doctor Octopus

Robert Callaghan/Yokai | Alistair Krei | Mr. Yama

Obake | High Voltage | Globby | Baron Von Steamer | Momakase | Ned Ludd | Mel Meyer | Mad Jacks | Mr. Sparkles | Noodle Burger Boy | Orso Knox | Trina | Diane Amara | Chris | Nega-Globby | Mayoi | Supersonic Sue | Hardlight | El Fuego | Sirque | Supersonic Stu | Chief Cruz's Father's Killer

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