NOTE: This article is about the incarnation of Madame Viper from the X-Men film series. The mainstream version can be found here: Madame Viper.
A chemist, a nihilist, a capitalist, a mutation. A viper.
~ Viper describing herself
Ophelia Sarkissian, better known as Madame Viper, is the secondary antagonist of the 2013 superhero film The Wolverine. She is a beautiful, yet evil and mysterious woman who used snake-like powers to poison and/or kill others.
In 2012, Viper was met by Ichirō Yashida during his trip to the U.S.A, looking for a medic and hired her as his oncologist. She was first seen tending a sick Yashida, as Wolverine and Yukio enter to talk to him.
Later that night, she violently kisses Wolverine and infects his healing factor with a nano-bettle. He wakes up to discover that Yashida has died.
Next day she attends Yashida's funeral, in which a fight begins with an attack from the Yakuza. During the battle, she tapes Wolverine being injured while fighting, and also kills a Yakuza thug that threatened her with a gun. Wolverine escapes with Yashida's grandaughter Mariko.
That night she reunites with Black Clan ninja Harada who is forced to chase Wolverine and Mariko after Viper uses her powers on him.
A few days later the Black Clan rescues Mariko from her father Shingen. Viper confronts him and stabs him with a poisoned pen; he dies later in a fight with Wolverine. Mariko is brought to her grandfather's factory in which Viper sends her to sleep after injecting her.
Later, Wolverine is captured by the Black Clan and restrained to a machine by Viper, who taunts him and reveals a plan to extract his healing and pass it to the Silver Samurai. Mariko interferes and the machine breaks, forcing everyone to flee. Viper is shot by Harada, and falls onto a bridge. However, she doesn't die and regenerates her skin to heal herself.
As the battle continues, Yukio arrives at the factory and both engage in a fierce fight, in which Yukio wrapes a wire in Viper's neck and turns on the elevator. The elevator then collides with Viper's head, snapping her neck and leaving her corpse hanging.
Viper was a mutant that was invulnerable to all the toxins known to Man, including (as she states) the toxin that is man himself.
She also possesses snake-like abilities like a tongue, producing venom, and regenerating her skin.
She is a skilled scientist, and a skilled hand-to-hand combatant, managing to be a match for Yukio, through she ended up killed by her.
It is also possible that she was a good spy, especially if she was asked to be discreet. She revealed this to Wolverine when he was asking for answers.
Madame Viper dies as she is being hanged in an elevator shaft after having her neck snapped