The Manticore is a hostile monster which featured in the Percy Jackson book and its film adaptations. Essentially, there are two versions of the featured monster in the franchise: One whom having human alias Dr. Thorn in the third book titled The Titan's Curse and the other as Luke Castellan's unnamed Manticore henchman in the 2013 film Percy Jackson and the Olympians: Sea of Monsters.
In either versions, they were served as supporting antagonists as both versions were affiliated with Luke and Kronos.
The book version of the monster is a male manticore under the alias of Dr. Thorn who likes all monsters, capable of shapeshifting into a human form as means to blend in human society. Dr. Thorn used this said alias in order to pose as a teacher at a military school called Westover Hall.
When Percy Jackson, Annabeth Chase, and Thalia Grace arrive at Westover Hall because Grover Underwood claims to have found two incredibly strong demigods; siblings Bianca and Nico di Angelo, they are stopped by Dr. Thorn and another teacher called Mrs. Gottschalk. Thalia uses the Mist to fool Mrs. Gottschalk into thinking that she, Percy and Annabeth are students along with Grover, Dr. Thorn is not completely convinced. During the dance the school is having, Dr. Thorn takes the two children and Percy rushes after them. When he enters the hallway, he finds Nico and Bianca, but Dr. Thorn stabs Percy with a spike he shot from his scorpian tail and reveals himself to be a manticore. Being unable to fight him in his weakened state, Percy goes along with the manticore and tried to contact Grover using his Empathy Link. The manticore reveals that he is under orders from the General (who is actually the Titan Atlas) to capture the two half-bloods in order to recruit them in Kronos' army.
However, as their transportation arrives, the manticore is attacked by Annabeth, Grover, and Thalia. The manticore is forced to use his original form to hold them off until Artemis and her Hunters arrive, claiming the manticore as their prey. Annabeth jumps on his back and stabs him with her knife, but it jumps off the side of the cliff and vanishes, bringing Annabeth with him as a prisoner. Artemis later questions Percy about the manticore and agrees to hunt it and the monster he claimed they would have soon. The manticore later delivers Annabeth to Luke Castellan, who uses her as bait in order to lure Artemis into a trap.
The manticore appears again in the presence of the General and Luke. He informs the two of Zoë Nightshade and her companions, currently questing for Artemis. The General belittles the manticore for his lack of results and denies him his request for a command of his own. The General then sends the manticore out of the room.
The manticore later appears again, cornering the questers on a dock. He claims that he will defeat the demigods himself in order to prove himself, but keeps them alive so they can witness Thalia killing the Ophiotaurus in order to defeat the gods. Thalia is tempted by the possibility but refuses. The manticore then attacks and almost kills them all until Percy sends an Iris Message to camp and pleads with Mr. D for help. The manticore is then covered in vines shortly after and is turned to dust.
Unlike Dr. Thorn who featured in the book, this version of Manticore appeared behaving much like a feral war dogs, but still loyal to its superiors includes Luke and its gender was unknown albeit presumed to be male.
The manticore first appears on Luke's ship Princess Andromeda. It stops Percy Jackson, Annabeth Chase, and Tyson from escaping. After the gang escapes the brig they sneak by it while it's sleeping near the door.
It appears at Polyphemus' lair during the reviving of Kronos. Percy runs to battle Kronos, but the manticore stops him. Percy and the manticore fight, but it knocks him down. It leaps at Percy but gets hit by a flying rock. After Percy defeats Kronos, the manticore reappears and stabs Annabeth from behind. Clarisse and Grover go to fight it. Grover distracts it while Clarisse chops off its tail. It destroys the manticore turning it to stone and crumbling to dust.