People, people, you worry too much! The body is perfect shape!
~ Mayor Phlegmming dishonestly assuring the reporters that the body is in perfect shape.
Son, do me a favor and read what it says on your arm. [Drix: 'For the temporary relief of symptoms associated with...'] Exactly! Temporary. You're nothing but a wannabe, a placebo, a generic brand, marked down, over-the-counter, useless Tic-Tac! [Drix gasps in shock] NOW, GET OUT OF MY BODY!
~ Mayor Phlegmming telling Drix that he outlived his purpose.
I wonder what this does?
~ Mayor Phlegmming's last words before pressing the "Do not touch" button and getting ejected out of Frank's body as a fart, getting killed.

Mayor Charles Phlegmming, or better known as Mayor Phlegmming, is the secondary antagonist of the 2001 Warner Bros. film Osmosis Jones. He was the corrupt mayor of the City of Frank, before being beaten by his political rival Tom Colonic.

He was voiced by William Shatner, who also played James T. Kirk in the Star Trek franchise, Kazar in The Wild, General Shanker in Escape From Planet Earth and Two-Face in Batman vs. Two-Face.


Phlegmming is first shown in the movie as he is being followed through the cerebellum hall by news reporters repeatedly asking him questions on the various problems in Frank DeTorre's body. He brushes off their concerns and dishonestly assures them that the body is in perfect shape. When he reaches his office, his secretary, Leah Estrogen shows him his political opponent Tom Colonic's new campaign ad, which he views with extreme annoyance. This makes him decide to double down on Frank's consumption of junk food, despite Leah's concerns. He also illegally controls Frank's thoughts and has him decide to take a cold pill against Leah's wishes. 

The next day, Phlegmming appears on TV and gives a speech about a vacation to the Annual Chicken Wing Festival in Buffalo, New York. A minute later, Osmosis Jones and Drixenol Koldreliff comes to Phlegmming's office after Jones and Drix narrowly stop a runny nose. Jones tells the mayor his suspicions that the malevolent virus called Thrax may be more than just a cold and Leah suggests that they put the city on high alert. Phlegmming, however, chooses to ignore Jones' warning, a decision that would haunt him later, though he does threaten to throw Jones out of the city and put him in Frank's next nosebleed if he speaks about a virus.

Later, after Jones and Drix destroy a nightclub inside a zit on Frank's forehead while uncovering Thrax's scheme to kill Frank, Phlegmming is furious and decides to close down the investigation and fire Jones. He then orders Drix to leave Frank's body through the bladder. Fortunately, although Jones relapses for a while, he didn't truly give up, and he, along with Drix, disobeys Phlegmming's orders and tries to stop Thrax.

Thrax infiltrates the brain of Frank, and steals Frank's DNA chromosome. This causes Frank's temperature to rise to hazardous levels, which gives an intense fever to DeTorre, almost causing him to die. Meanwhile, after Leah tells Phlegmming off for not caring enough about Frank's body, he, Phlegmming could do nothing but watch as the City of Frank burned to the ground.

Jones chases Thrax onto Shane's false eyelash. There, the two have a confrontation, Jones winning in the end when Thrax falls off the eyelash into a bottle of rubbing alcohol, which dissolves him to death. Jones returns to Frank's brain and restores the City of Frank by putting the DNA chromosome back where it belongs.

Fortunately, after the massive disaster, Phlegmming faces a massive scandal. In the mayor re-election, his rival wins in a landslide, and Phlegmming is impeached, removed from office, and demoted to an Intestinal Cleaner while Jones and Drix are declared heroes for saving Frank with Jones getting his old job back.

While working at his new job, Phlegmming presses a button that was labeled with, "Do not touch." This caused him to be blown out of Frank's body, as a fart, causing his demise as he goes out of the City of Frank.


Phlegmming is an arrogant, careless, and cruel control freak whose only concern is to stabilize his position as Mayor. Everything else that he does is only for his selfish interests, not for Frank's or his citizens. The only time he is shown feeling regret and remorse for his actions was when his mayoralty was at stake as Frank's temperature neared a fatal 108 degrees.


  • Some fans claim Mayor Phlegmming to be the true antagonist of the film, as it was his fault Frank contracted Thrax. However, Thrax is still easily the main villain, as he is more malevolent and had bigger plans.
  • Had he stopped being the Mayor of Frank (or he had been a better mayor) by the beginning, Frank might have had less of a chance of contracting Thrax.
  • Despite his questionable way of keeping Frank "healthy", he does seem to show concern for Frank getting ill.
  • The late Brian Murray, the late Gregory Peck, Colm Meaney, Alan Cumming, James Woods, Christopher McDonald, Tommy Lee Jones, Eric Roberts, the late Patrick McGoohan and the late Ernest Borgnine were all considered for the role of Mayor Phlegmming before William Shatner was cast.
  • He is the first animated character to be voiced by William Shatner.
  • The fact that he's basically the leader of all the cells in Frank, but is utterly motivated by self-interest rather than morality sort of makes him an anti-thesis to William Shatner's most famous character, James T. Kirk from Star Trek.
  • Mayor Phlegmming has some similarities to the 45th President of the United States, Donald Trump, as both of them use lies, false information, and disregard a dangerous disease to secure their power, only for them to lose their positions of power.


           WBLogo.png Villains

Animated Features
Meowrice | Meowrice's Henchmen | Mouse King | Mouse Queen | Joker | Phantasm | Salvatore Valestra | Arthur Reeves | Chuckie Sol | Buzz Bronski | Grundel Toad | Berkeley Beetle | Mr. Mole | Mrs. Toad | Ms. Fieldmouse | Queen Gnorga | King Llort | Darla Dimple | Max | Mrs. Prysselius | Thunder Karlsson and Bloom | Ruber | Griffin | Ruber's Minions | Bladebeak | Eric Cartman | Saddam Hussein | Sheila Broflovski | Satan | Mr. Garrison | Chef | Randy Marsh | Shelly Marsh | Gerald Broflovski | Kent Mansley | Kralahome | Master Little | The Jokerz (Dee Dee Twins, Chucko & Woof) | Count Grisham | Cheswick | Mojo Jojo | Gangreen Gang | Anubis | Seto Kaiba | Dark Yugi | Pegasus J. Crawford | Mokuba Kaiba | Marik Ishtar | Ebenezer Scrooge Puppet | Barkis Bittern | Maudeline Everglot | Stan Beals | Wasps | Noah the Elder | Leopard Seal | Aguila | Stone Generals (Gato & Mono) | Karai | Foot Clan | Eddy's Brother | Kanker Sisters | Kevin | Sarah | Surtr | Nyra | Kludd | Allomere | Jatt and Jutt | Pure Ones | Lord Business | Super Secret Police (Bad Cop & Sheriff Not-A-Robot) | Duplo Aliens | Mr. Ross | Future Mordecai | Rigby | Benson Dunwoody | Muscle Man | Hunter | Pigeon Toady | Wolf Pack | Penguins | Joker (Lego) | Harley Quinn (Lego) | Phantom Zone Criminals | Catwoman (Lego) | Poison Ivy (Lego) | Two-Face (Lego) | Lord Garmadon | Slade (Teen Titans Go!) | Balloon Man (Teen Titans Go!) | Lex Luthor (Teen Titans Go!) | Stonekeeper | Rex Dangervest | Velociraptors (Lego) | Foot Clan (Shredder) | League of Assassins (Ra's al Ghul (Batman vs. TMNT), Ubu (Batman vs. TMNT) & Talia al Ghul (Batman vs. TMNT)) | Joker (Batman vs. TMNT) | Harley Quinn (Batman vs. TMNT) | Scarecrow (Batman vs. TMNT) | Mr. Freeze (Batman vs. TMNT) | Poison Ivy (Batman vs. TMNT) | Bane (Batman vs. TMNT) | Two-Face (Batman vs. TMNT) | Penguin (Batman vs. TMNT) | Hexagon (Trigon (TTG) & Trigon (Original)) | Spinel | Pink Diamond | Scorpion | Quan Chi | Shang Tsung | Goro | Shao Kahn | Kano | Baraka | Reptile | Moloch | Motaro | Dick Dastardly (2020) | Muttley (2020) | Rotten Robots | Dusty | Cerberus

Live Action Films
Rhedosaurus | Giant Carpenter Ants | Jack Torrance | Hotel Caretaker | Lorraine Massey | Socs (Bob Sheldon, Randy Adderson, Paul Hoden & David) | Mrs. Cade | Scut Farkus | Grover Dill | Stripe | Ruby Deagle | Gremlins | Mama Fratelli | Audrey II | Orin Scrivello | Mr. Igoe | Max | David | Sergeant Nagata | Beetlejuice | Sandworms | Joker | Bob the Goon | Alicia Hunt | Carl Grissom | Max Eckhardt | Vinnie Ricorso | Joe Chill | Witches (Grand High Witch, Susan Irvine, Nicola Cuttle, Pamela, Lois Leffour, Mildred, Elizabeth, Henrietta, Jacqueline & Beatrice) | Brain Gremlin | Daffy | George | Lenny | Secretary Gremlin | Bat Gremlin | Electric Gremlin | Cushing Catheter | Penguin | Max Shreck | Catwoman | Red Triangle Circus Gang | Charles "Chip" Shreck | Switchblade Sam | Dr. Charles Nichols | Frederick Sykes | Lawrence Van Dough | Ferguson | HAL 9000 | Lestat | Armand | Santiago | Clarice Kensington | Miss Minchin | Riddler | Two-Face | Sugar | Spice | NygmaTech (Frogmen) | Neon Gang | Salvatore Maroni | Jonas Miller | Mr. Swackhammer | Monstars | Martians (Martian Leader, Martian Ambassador & Martian Girl) | John Wesley | Poison Ivy | Mr. Freeze | Bane | Grant Frost | Agent Smith | Cypher | Agents (Agent Jones, Agent Brown & Agent Johnson) | Susan McCallister | Jim Whitlock | Mako Sharks | William Wharton | Percy Wetmore | Jeremy Melton | Mr. Tinkles | Thrax | Mayor Phlegmming | Bruiser | Joe Cramp | Thrax's Henchmen | Lord Voldemort | Quirinus Quirrell | Draco Malfoy | Severus Snape | Mountain Troll | Scrappy-Doo | N' Goo Tuana | Zarkos | Demons | Luna Ghost | Akasha | Spiders (Consuela & Tank) | Lucius Malfoy | Basilisk | Gilderoy Lockhart | Acromantula (Aragog & Acromantula Colony) | Mr. Gray | Mr. Chairman | Bob Smith | Robo Dog | Jonathan Jacobo | Peter Pettigrew | Dementors | Marge Dursley | Clara Dalrymple | Sir Trenton | Trenton's Pride | Ra's al Ghul | Scarecrow | Carmine Falcone | League of Shadows (Decoy of Ra's al Ghul) | Victor Zsasz | Joe Chill | Arthur Slugworth | V | Barty Crouch Jr. | Nagini | Bellatrix Lestrange | Adam Sutler | Lewis Prothero | Norsefire | Peter Creedy | Colonel Coetzee | Captain Poison | Zodiac Killer | Arthur Leigh Allen | Xerxes | Dolores Umbridge | Agent 23 | Siegfried | Dalip | Joker | Two-Face | Sal Maroni | Gambol | Joker's Thugs | Principal Deedle | Ezekial Gallows | Prudence Prufrock | Lord Henry Blackwood | Lord Coward | Esther Coleman | Decoy Queen | Kitty Galore | Paws | Mayor Brown | Wanda Grubwort | Lake Monster | Mal Cobb | Blue Jones | Angelique Bouchard | Dr. Julia Hoffman | Bane | Talia al Ghul | Barsad | Catwoman | John Daggett | Tom Buchanan | Jay Gatsby | Myrtle Wilson | George Wilson | Daisy Buchanan | Precursors | Kaiju (Trespasser, Knifehead, Mutavore, Otachi, Leatherback, Raiju, Scunner & Slattern) | Artemisia | M.U.T.O. | Dr. Mann | Victoria Vinciguerra | Léon Rom | Skull Devil | Preston Packard | It | Bowers Gang (Henry Bowers, Patrick Hockstetter, Belch Huggins & Vic Criss) | Alvin Marsh | Butch Bowers | Mathias Vogel | Ana Miller | Nolan Sorrento | Innovative Online Industries (I-R0k, F’Nale Zandor & Sixers) | Claire Wyden | Brett Wyden | George, Ralph and Lizzie | The Meg | Jack Morris | Shere Khan | Tabaqui | Howard Clifford | Ditto | Sebastian | Ann Laurent | King Ghidorah | Rodan | Alan Jonah | Asher Jonah | Emma Russell | The Banana Splits (Fleegle, Drooper, Snorky & Bingo) | Poppy | Karl | Leo | Cry Baby | Kelly | The Principal | The Biology Teacher | Tom Rogan | Arthur Fleck | Penny Fleck | Randall | Clowns (Joker) (Clown & Ambulance Clown) | Wall Street Three | Penny Fleck's Boyfriend | Rose the Hat | The True Knot | Andrei Sator | Priya Singh | Terrance Mendoza | Butch | Mechagodzilla | Apex Cybernetics (Walter Simmons, Ren Serizawa, & Maia Simmons) | Warbats | Hellhawks | Shang Tsung | Sub-Zero | Mileena | Reiko | Kano | Kabal | Goro | Reptile | Nitara | Shao Kahn

Daffy Duck | Sylvester | Tasmanian Devil | Wile E. Coyote | Elmer Fudd | Yosemite Sam | Marvin the Martian | Instant Martians | Gossamer | Tom | Jerry | Spike

The Grinch | Cousin Mel | I.M. Slime | Snow Miser | Heat Miser | North Wind

See Also
Adventure Time Villains | Batman Villains | Ben 10 Villains | Catwoman Villains | Cats & Dogs Villains | Cartoon Network Villains | DC Animated Movie Universe Villains | DC Extended Universe Villains | DC's Legends of Tomorrow Villains | Eraser Villains | Game of Thrones Villains | Gremlins Villains | Hanna-Barbera Cinematic Universe Villains | Harry Potter Villains | Lethal Weapons Villains | Looney Tunes Villains | Melanie Martinez Villains | Middle-Earth Villains | MonsterVerse Villains | Mortal Kombat Villains | New Line Cinema Villains | Pokemon Villains | Powerpuff Girls Villains | Primal Villains | Regular Show Villains | Rick and Morty Villains | Robot Chicken Villains | Rush Hour Villains | Samurai Jack Villains | Scooby-Doo Villains | Steven Universe Villains | Superman Villains | The Banana Splits Movie Villains | The Conjuring Villains | The LEGO Movie Villains | The Matrix Villains | Tom and Jerry Villains | TMNT Villains | Wild Wild West Villains | Xiaolin Showdown Villains | Yu-Gi-Oh! Villains

           Osmosis Jones Villains

Thrax | Mayor Phlegmming | Joe Cramp | Bruiser | Scabies

Scarlet Fever | Ernst Strepfinger | Protozilla | Smirch | Rhoda Virus | Nick O' Teen | Tar | Butane | Carbon Monoxide | Sal Monella | Sylvian Fisher | General Malaise | Professor Nightmare | Pneumoniac | Chief Maximus | Mother Worm | Shane | Stickety Lipid | Cryo | Lead Head Gang | Mitosis Jones | Billy Blob Bile

Community content is available under CC-BY-SA unless otherwise noted.