Megamind is the titular protagonist of DreamWorks' 21st full-length animated feature film of the same name. He is a blue alien with a genius-level intellect and desire for affection. He has a dark past that involves his rival, who would become Metro Man, keeps on getting what he wants, making him become the villain that he is. Since then, Megamind and Metro Man would fight each other which the result is always the latter winning. He also has a talking sapient fish named Minion, who has been his henchman and best friend since childhood. He also has created robots called Brainbots, who do his bidding for him, even going so far through disguising themselves as civilians.
In the beginning of the film, Megamind and Minion (as infants) were sent away by Megamind’s parents (who were presumably scientists) in a space pod to escape the destruction of their home planet by a black hole. During the journey to Earth, another space pod flew by, with a baby Metro Man, who was also sent away to escape from the black hole threatening his home planet (which, coincidentally, seemed to be a rival planet to Megamind’s). Both pods land in Metro City, but results vary: while Metro Man's pod landed in the home of a loving, and presumably wealthy, couple who raised him as their own son, while Megamind's pod landed in the Metro City prison, where the prisoners raised him. The prisoners teach little Megamind all about right and wrong (mostly wrong) using "Baby Super-villains" CDs, DVDs, and cards. During their childhood life, Metro Man was popular among the kids while Megamind was ridiculed due to his appearance and brilliance, while also due to the fact that Metro Man was the more favorable candidate, which would eventually lead to Megamind becoming the villain he was and Metro Man's rival.
Feud with Metro Man
The feud between Megamind and Metro Man remain constant until one day Megamind kidnaps news reporter Roxanne Ritchi and lures Metro Man into a trap near an observatory, where Metro Man becomes weakened by the copper lining inside the observatory before Megamind's death ray destroys the observatory, leaving nothing for Metro Man to be left as a skeleton with his cape. Upon witnessing this, Megamind revels in his victory against Metro Man and takes over Metro City to himself. Though at first, Megamind feels good of his victory, but later on, he feels isolated and depressed, as he finds his villainy with no meaning without anyone to stop him. He does this after several days of committing crimes with no one to stop him.
Creating a New Hero
While attempting to destroy the museum dedicated to Metro Man, Megamind disguises himself as its curator Bernard to prevent Roxanne from finding him. It is then Roxanne made a comment that inspired the disguised Megamind to create a superhero to battle against him. Deciding to keep things back in balance again for the good of Metro City, Megamind creates a serum containing Metro's Man powers, coming from Metro Man's DNA found in his old cape. He intends to inject the serum to a person worthy enough to defeat him and continue the greater good. Just before he could do so, Roxanne sneaks into his lair with her cameraman Hal Stewart, intending to find out what Megamind's plans are. The resulting chaos ended up with the serum accidentally injected into Hal, who would later inherit all of Metro Man's powers. Taking the opportunity, Megamind heads onward to Hal's apartment, disguises himself as Hal's "Space-Dad", training him to become a hero for days. During the training, Megamind gives Hal his superhero name "Titan" to which Hal misinterprets as "Tighten". At the same time, Megamind develops a relationship with Roxanne under his Bernard disguise. Unfortunately, unknown to Megamind, Hal himself also has feelings for Roxanne, intending to use his own powers to win her heart for himself, as he believes that being a hero means to get the girl for himself rather than doing the greater good.
As Megamind continues his date, he starts to lose interest in villainy, causing Minion to leave him after a fallout, feeling somewhat betrayed after Megamind says some nasty things to him. Later on a dinner date, Megamind's Bernard disguise falters away, leaving Roxanne to dump him and causing him to forget where he left his invisible car that contains the same defuser gun that injected the powers to Hal. Deciding to continue with his plan, Megamind waits for Tighten to arrive and fight him, only to seek him out again in his apartment, where Megamind discovers that Tighten has decided to use his powers for nefarious purposes, as it was evident of Tighten having stolen lots of money, an arcade video game, an ATM machine, a bike and electronics. Tighten then reveals that he originally tried to become a hero for Roxanne Ritchi, and found out about "Bernard" and her relationship, and now wants to establish a partnership with Megamind, but the latter, outraged by seeing his "hero" turning out to be a selfish person, refuses and instead goads Tighten to fight him by revealing his "Space-Dad" and "Bernard" disguises.
As planned, Titan fights against Megamind, unleashing his rage against him, and finally manages to defeat him, berating him for "stealing" Roxanne and tricking him. Megamind initially congratulates Titan for his victory and awaits to go back to jail again, but Titan wants to kill him instead of turning him over to the authorities. Shocked, Megamind orders his Brain-Bots to initiate a backup plan: to contain Titan in a copper-based sphere. However, this fails forcing Megamind to flee while Titan himself starts to terrorize Metro City as its new villain, causing more chaos to the city than Megamind has ever done while continuing to search for Megamind. Confused about the inconsistency of the copper as a weakness, Megamind turns to Roxanne, apologizing to her for his actions on her and convincing her to find a way to stop Tighten.
To start off, they manage to track down Metro Man's old lair, where they are surprised to see that Metro Man is actually alive, demanding an explanation for what happened. Feeling somewhat remorseful, Metro Man explains to Megamind and Roxanne that he felt tired battling against Megamind, as he feels that Megamind is having emotions during their feud. Metro Man also explained that, like Megamind, he never made a choice to decide what he wants to be in life despite his success as a superhero, and decides to retire by faking his death to pursue a career as a musician. Megamind understands Metro Man's intentions, but pleads to him to stop Titan, to which Metro Man respectfully refuses, knowing it would be against his vow to be making a choice in life. Eventually, Metro Man encourages Megamind to stand up for the greater good and fight back against Titan, to which Megamind refuses, stating that he will always be the failing villain to be. Having no more leads to stop Titan, Megamind decides to turn himself back to prison, intending to pay the price for his actions, including creating Titan.
With the supers no longer helping, Roxanne calls to Titan, trying to appease to his conscience, but Titan retorts that by denying that he has got any good in him, and instead kidnaps Roxanne and tying her up in the top of Metro Tower, intending to goad Megamind out to fight him by threatening Roxanne's life. Seeing this on TV, Megamind pleads the Warden to release him, even going so far to apologize and pay for the mistakes he done in the past (including hurting his dear best friend, Minion). In an act of surprise, Minion disguises himself as the Warden, accepting Megamind's apology, and the two head off to stop Titan in his tracks, while the real Warden (who is tied up by Minion to help Megamind) wishes them good luck.
Megamind and Minion arranged a plan of rescue and action, by having the latter to disguise himself as the former to save Roxanne with the help of the Brain-Bots, as well as the former to disguise himself as Metro Man to track down Titan and verbally berate him for his actions. The plan somehow worked, although Minion ended up being stabbed by the tower's rod near a water fountain by Titan, while Megamind, under his Metro Man disguise, orders Titan to leave Metro City and never return. Titan agrees to go, but later returns after realizing that the "hero" said the word "Metrosity", something which only Megamind says, as he has trouble saying some of the simple words, such as "hello" for "ollo". Titan then calls out Megamind for fooling him. Megamind, however remains unfazed, saying that it was Hal's entitlement and refusal to move on from Roxanne's rejection that led to him going on a crime spree. Seeing that it didn't work and that Hal still wishes to kill him, Megamind continues fighting against Titan to no avail, that is until Roxanne discovers where Megamind left his invisible car and his defuser gun the night she dumped him. She explains this to Megamind, leaving him to finally get hold of the defuser gun, but Tighten throws him up into the sky, hoping that he will fall to his death. Just as things are about to go down when Titan decides to finish off Roxanne near the water fountain, Megamind dehydrates himself into a cube, landing into the water, where he re-hydrates himself and uses the defuser gun to remove all of Titan's powers for good. Having defeated Hal for good, Megamind goes in to save Minion by throwing him into the fountain water, since fish need water to survive, thanking him for his help. It was then the citizens of Metro City cheered for Megamind as their new hero. However, because of his past, things are awkward between them at first.
Feeling good about this, Megamind realizes that destiny itself is the path he can choose for himself. Feeling capable to becoming a real hero, Megamind arranges the Brain-Bots to repair the destruction he and Hal has done to Metro City as retribution, and the Metro Man museum gets dedicated to him. As for Hal, he gets arrested and thrown into Megamind's old cell for a life sentence as punishment for his crimes against Metro City. During a celebration of Megamind as the new hero, a disguised Metro Man within the audience silently gives his congratulations to Megamind, having known that he had some good left in him. To make things better, Roxanne develops her relationship with Megamind in honor of his actions for her. The film ends with Megamind, Roxanne, Minion, and everyone in Metro City dancing to the tune of Michael Jackson's Bad.