Mekanique comes from a small elite ruled despotically over a downtrodden slave race. The elite were in danger of being overthrown due to a woman named Maria, who led the slaves into open rebellion. To combat this, an evil scientist named Rotwang created her and gave her the ability to travel back in time for the purpose of making sure Maria would never be born.
She arrived in the headquarters of the All-Star Squadron; badly damaged, Mekanique attacked Firebrand. She revealed that Mekanique shows the heroes an image of a child about to be killed in a car accident and so causes the effects to take hold, blanking out Robotman's memory so that he cannot warn his fellow Squadron members.
Sometime after Mekanique meets Per Degaton while he was still an assistant at the Time Trust. She convinced Degaton to help her in her fight against the All-Star Squadron, in exchange for teaching him the secrets of time travel. It is here where Helena's vision comes true in a different sense in a model of a futuristic metropolis.
However, by 1947, Degaton, Mekanique, and a new ally, Professor Malachi Zee, have managed to build a working time machine. Mekanique gave Degaton a crystal that would give power to the time machine to travel through time. Degaton lunged at the machine to prevent it from traveling to the future without him, but fails. When Mekanique suggests they wait forty years for the machine to reappear, Degaton snaps and buries Mekanique's head.
Forty years later, anique. She appeared during the time of the Crisis On Infinite Earths in 1985 to manipulate Commander Steel into kidnapping and tampering with his grandson in order to free the two heroes from her influence, she vanishes. She reappeared in Los Angeles a few years later to bring an aged Degaton who was struck by a car back to life, and the two of them attack Infinity, Inc. at the scheduled return site of the time machine. When the time machine appears, it contains not only the body of Zee, but a younger Degaton. This duplicate version of Degaton had been created by the chronal energies of the time machine as Degaton had lunged at the machine in 1947. The elder Degaton vanishes from existence at the appearance of his younger self, but fearing that the young Degaton would destroy her again, Mekanique activates a self-destruct that kills Degaton along with herself.