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Jurassic World: Dominion Dominates Fandom Wikis - The Loop
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I should've let you die!
~ Sinister after Morph shoots him.
Your genetic material will be the foundation, the master bloodline for an unbeatable race of mutants who will be my slaves. Through you, I shall give birth to the future.
~ Sinister when he kidnaps Cyclops and Jean.
Nathaniel Essex, better known as Mister Sinister, is the primary antagonist in season 2 of X-Men: The Animated Series, serving as a recurring villain throughout the rest of the series. He is a renegade geneticist that is obsessed with studying and controlling mutations for his own evil purposes.
Dr. Nathaniel Essex was a firm believer in Charles Darwin’s theory of natural selection. Believing that this could result in mankind evolving into godhood, he began conducting (sometimes torturous) experiments on mutants in hopes to evolve himself and save his wife Rebecca Grey, who had a terminal illness that no one knew how to cure. After concocting a serum that turned his skin chalk-white and gave him regenerative healing abilities, the townspeople believed he had gone mad when they learned of his experiments, and he fled across the world, chased by James Xavier but to no avail. With his newfound powers leaving him unable to age, he took an interest in finding those who could help him make the world a much more evolved place, and took on the name "Mr. Sinister" from that point on.
Mr. Sinister makes his first chronological appearance in "Till Death Do Us Part". After Morph was killed by Sentinels at the start of season 1, Sinister brought him back to his lair to revive and brainwash him into his minion, telling him to get his revenge on the X-Men for leaving him to die, which he does by briefly turning them against each other. Meanwhile, Sinister abducts Cyclops and Jean Grey (both of whom he's observed throughout their whole lives) during their honeymoon, planning to create an army of mutant slaves using their DNA. The remaining X-Men arrive to stop him, and Cyclops breaks free and wounds Sinister with his optic red laser blasts, forcing him and the Nasty Boys to retreat. Meanwhile, Professor X and Magneto are stuck in the Savage Lands, de-powered thanks to the island's technology made by Sinister himself.
In the episode "Bloodlines", Sinister orders Mystique to defeat the X-Men so she can reclaim her foster daughter, Rogue. In the season 2 finale "Reunion", Sinister kidnaps Magneto and most of the X-Men except for Wolverine, planning to once again harvest their DNA. Wolverine meets Ka-Zar while fleeing in the jungle, and together they perform a prison break to free the X-Men as well as the Savage Lands' previous inhabitants. During an epic battle, Sinister blows up into pieces due to the combined laser blasts of Cyclops and Morph, and Jean uses her telekinesis to fly the pieces away so it'll take a very long time to build himself back together.
Sinister doesn't reappear until "Beyond Good and Evil", in which he kidnaps at least two psychics (including Jean Grey) for Apocalypse, knowing full-well that he plans to recreate existence. When Magneto betrays Apocalypse and Cable and Bishop arrive to free the psychics, Sinister and the Nasty Boys quickly retreat from the Axis of Time while they still can. His last appearance is in "The Phalanx Covenant", where the titular Phalanx destroys his lab and minions, leaving him no choice but to side with Beast, Forge and Magneto to stop it. At one point, he pushes Moira MacTaggart out of the group's escape plane so she doesn't assimilate the entire aircraft, showing that he's only working with others to save his own skin, which even Magneto points out at the end of the episode. Once the Phalanx is defeated, Sinister runs away into a dark alleyway, never to be seen again.