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I should've let you die!
~ Sinister after Morph shoots him.
Your genetic material will be the foundation, the master bloodline for an unbeatable race of mutants who will be my slaves. Through you, I shall give birth to the future.
~ Sinister when he kidnaps Cyclops and Jean.

Nathaniel Essex, better known as Mister Sinister, is the primary antagonist in season 2 of X-Men: The Animated Series, serving as a recurring villain throughout the rest of the series. He is a renegade geneticist that is obsessed with studying and controlling mutations for his own evil purposes.

He was voiced by Christopher Britton.

Biography

Dr. Nathaniel Essex was a firm believer in Charles Darwin’s theory of natural selection. Believing that this could result in mankind evolving into godhood, he began conducting (sometimes torturous) experiments on mutants in hopes to evolve himself and save his wife Rebecca Grey, who had a terminal illness that no one knew how to cure. After concocting a serum that turned his skin chalk-white and gave him regenerative healing abilities, the townspeople believed he had gone mad when they learned of his experiments, and he fled across the world, chased by James Xavier but to no avail. With his newfound powers leaving him unable to age, he took an interest in finding those who could help him make the world a much more evolved place, and took on the name "Mr. Sinister" from that point on.

Mr. Sinister makes his first chronological appearance in "Till Death Do Us Part". After Morph was killed by Sentinels at the start of season 1, Sinister brought him back to his lair to revive and brainwash him into his minion, telling him to get his revenge on the X-Men for leaving him to die, which he does by briefly turning them against each other. Meanwhile, Sinister abducts Cyclops and Jean Grey (both of whom he's observed throughout their whole lives) during their honeymoon, planning to create an army of mutant slaves using their DNA. The remaining X-Men arrive to stop him, and Cyclops breaks free and wounds Sinister with his optic red laser blasts, forcing him and the Nasty Boys to retreat. Meanwhile, Professor X and Magneto are stuck in the Savage Lands, de-powered thanks to the island's technology made by Sinister himself.

In the episode "Bloodlines", Sinister orders Mystique to defeat the X-Men so she can reclaim her foster daughter, Rogue. In the season 2 finale "Reunion", Sinister kidnaps Magneto and most of the X-Men except for Wolverine, planning to once again harvest their DNA. Wolverine meets Ka-Zar while fleeing in the jungle, and together they perform a prison break to free the X-Men as well as the Savage Lands' previous inhabitants. During an epic battle, Sinister blows up into pieces due to the combined laser blasts of Cyclops and Morph, and Jean uses her telekinesis to fly the pieces away so it'll take a very long time to build himself back together.

Sinister doesn't reappear until "Beyond Good and Evil", in which he kidnaps at least two psychics (including Jean Grey) for Apocalypse, knowing full-well that he plans to recreate existence. When Magneto betrays Apocalypse and Cable and Bishop arrive to free the psychics, Sinister and the Nasty Boys quickly retreat from the Axis of Time while they still can. His last appearance is in "The Phalanx Covenant", where the titular Phalanx destroys his lab and minions, leaving him no choice but to side with Beast, Forge and Magneto to stop it. At one point, he pushes Moira MacTaggart out of the group's escape plane so she doesn't assimilate the entire aircraft, showing that he's only working with others to save his own skin, which even Magneto points out at the end of the episode. Once the Phalanx is defeated, Sinister runs away into a dark alleyway, never to be seen again.

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Comics
0101 | Abomination | Absorbing Man | Absalom | Acolytes | Adversary | Ahab | A.I.M. | Akhenaten | Alan Lewis | Amanda Sefton | Ani-Mator | Annihilus | Apocalypse | Arcade | Archangel | Arclight | Arnim Zola | Avalanche | Awesome Android | Azazel | Badoon | Barbarus | Bastion | Baron Karza | Baron Wolfgang von Strucker | Batroc | Beef | Beetle | Black Tom Cassidy | Belasco | Beyonder | Black Box | Blastaar | Blockbuster | Blood Brothers | Bolivar Trask | Blob | Bogeyman | Boomerang | Brood | Brotherhood of Evil Mutants | Brainchild | Bulldozer | Bullseye | Burner | Cameron Hodge | Carnage | Cassandra Nova | Chameleon | Children of the Vault | Chimera | Clan Akkaba | Coach | Computo | Constrictor | Count Nefaria | Creeps | Crossbones | Dark Avengers | Dark Beast | Dark Phoenix | Dark X-Men | Deadpool | Demon Bear | Demogoblin | Doctor Doom | Doctor Octopus | Doctor Rice | Dracula | Egghead | Electro | Emma Frost | Erik Killmonger | Exodus | Fenris | Freedom Force | Friends of Humanity | Frightful Four | Frost Giants | Galactus | Gamesmaster | Graydon Creed | Green Goblin | Grizzly | Hammerhead | Hand | Hela | Hellfire Club | Henry Peter Gyrich | High Evolutionary | Hobgoblin | Holocaust | Horsemen of Apocalypse | HYDRA | Impossible Man | Jackal | Jack O' Lantern | J. Jonah Jameson | Juggernaut | Kang | Kid Omega | Kingpin | Killer Shrike | Klaw | Knull | Krakoa | Kraven | Lord Deathstrike | Lady Deathstrike | Legion | Leper Queen | Lilith | Living Monolith | Lizard | Loki | Mad Thinker | Madame Viper | Madelyne Pryor | Magneto | Magus | Malekith the Accursed | Mandarin | Marrow | Masters of Evil | Master Mold | Medusa | Maximus | Mesmero | Mikhail Rasputin | Mister Jip | Mister Negative | Mister Sinister | M.O.D.O.K. | Mojo | Mole Man | Moonstone | Morbius | Morlocks | Moses Magnum | Mutant Response Division | Mystique | Mysterio | N'Astirh | Namor | Nanny | Nekra | Neo | Nightmare | Nimrod | Nitro | Norman Osborn | Obnoxio the Clown | Omega Gang | Omega Red | Onslaught | Orphan-Maker | Ozymandias | Pandemonia | Phalanx | Piledriver | Pilgrimm | Predator X | Proteus | Psycho-Man | Puma | Punisher (Earth-95216) | Purifiers | Pyro | Quicksilver | Reavers | Red Ghost | Red Skull | Reverend Craig | Rhino | Right | Rogue | Ronan | Sabretooth | Sandman | Sat-Yr-9 | Sauron | Savage Land Mutates | Scarlet Witch | Scorpion | Sebastian Shaw | Selene Gallio | Sentinels | Serpent Society | Shadow King | Shadow Xavier | Shocker | Silver Sable | Silver Samurai | Simon Trask | Sinister Six | Skrulls | Spiral | Stranger | Stinger | Stryfe | Stephen Lang | Sublime | Sugarman | Super-Adaptoid | Super-Apes | Supreme Intelligence | Swarm | Thanos | Thunderball | Thunderbolt Ross | Tiger Shark | Tinkerer | Toad | Trevor Fitzroy | Typhoid Mary | Tyrannus | Unus | Vampires | Venom | Vulcan | Vulture | Wendigo | Whiplash | Whirlwind | White Rabbit | William Stryker | Wizard | Wrecker | X-Man | Xemnu | Xorn | Ymir | Zaladane

Movies
X-Men: Brotherhood of Mutants (Magneto, Mystique, Sabretooth & Toad) | Pyro
X2: William Stryker Jr. | Lady Deathstrike | Jason Stryker | Brotherhood of Mutants (Magneto, Mystique & Pyro)
X-Men: The Last Stand: Brotherhood of Mutants (Magneto, Dark Phoenix, Pyro, Juggernaut, Multiple Man & Mystique) | Omega Gang (Callisto, Psylocke, Quill, Arclight, Avalanche, Spike, Glob Herman & Phat) | Archangel
X-Men: First Class: Hellfire Club (Sebastian Shaw, Emma Frost, Azazel, Angel Salvadore & Riptide) | William Stryker Sr. | Magneto | Mystique
X-Men: Days of Future Past: Trask Industries (Bolivar Trask, William Stryker Jr. & Sentinels) | Magneto | Mystique | Toad | Horsemen of Apocalypse (Apocalypse)
X-Men: Apocalypse: Ashir En Sabah Nur/Horsemen of Apocalypse (Apocalypse, Magneto, Psylocke & Archangel) | Dark Phoenix | Mystique | William Stryker Jr. | Blob
X-Men: Dark Phoenix: Dark Phoenix | D'Bari (Vuk & Jones) | Brotherhood of Mutants (Magneto & Selene Gallio) | Mystique
The New Mutants: Essex Corp (Cecilia Reyes) | Demon Bear | Reverend Craig | Smiley Men

Television
X-Men (1992): Magneto | Sentinels | Sabretooth | Juggernaut | Apocalypse | Mesmero | Horsemen of Apocalypse | Mister Sinister | Omega Red | Brotherhood of Mutants (Mystique, Avalanche, Blob & Pyro) | Dark Phoenix | Master Mold | Bolivar Trask | Silver Samurai | Hellfire Club (Sebastian Shaw, Harry Leland, Jason Wyngarde, Donald Pierce & Emma Frost) | Reavers (Bonebreaker & Lady Deathstrike) | Supreme Intelligence | D'Ken | Deathbird | Graydon Creed | Red Skull | Toad | Sauron | High Evolutionary | Phalanx | Brood | Skrulls | Super-Adaptoid | Awesome Android | Mojo
X-Men: Evolution: Magneto | Brotherhood of Mutants (Mystique, Avalanche, Toad, Blob, Quicksilver & Scarlet Witch) | Pyro | Mastermind | HYDRA (Madame Viper & Omega Red) | David Haller | Juggernaut | Bolivar Trask | Sentinels | Apocalypse | Horsemen of Apocalypse | Mesmero | Sabretooth | Destiny | Arcade
Wolverine and the X-Men: Brotherhood of Mutants (Magneto, Mystique, Scarlet Witch, Juggernaut, Quicksilver, Avalanche, Blob, Pyro & Toad) | Dark Phoenix | Bolivar Trask | Sentinels | Sabretooth | Mutant Response Division (Colonel Moss) | Shadow King | Hellfire Club (Sebastian Shaw, Donald Pierce, Harry Leland, Selene Gallio, Emma Frost & Stepford Cuckoos) | Master Mold | Silver Samurai | Nitro | Mojo | Mister Sinister | Apocalypse
Marvel Anime: X-Men: Hellfire Club (Emma Frost, Martermind) | U-Men (Sublime)
Legion: Legion | Shadow King | Oliver Bird | Time Eaters
The Gifted: Sentinel Services (Jace Turner, Ed Weeks) | Trask Industries (Roderick Champell) | Ted Wilson | Hellfire Club (Fenris, Reeva Paype, Frost Sisters) | Benedict Ryan

Video Games
The Uncanny X-Men: Magneto | White Queen | Juggernaut | Sabretooth | Boomerang
X-Men: Madness in Murderworld: Arcade | Magneto | Juggernaut | Blob | White Queen | Mystique | Pyro | Wendigo | Silver Samurai
X-Men II: The Fall of the Mutants: Mystique | Avalanche | Blob | Pyro | Spiral
Spider-Man & X-men: Arcade's Revenge: Arcade | Carnage | Rhino | Apocalypse | Juggernaut | Selene Gallio | Sentinels | Master Mold
X-Men (1992): Brotherhood of Mutant Terrorists (Magneto, Mystique, White Queen, Juggernaut, Blob, Pyro, Wendigo & Living Monolith) | Sentinels
X-Men (1993): Magneto | Apocalypse | Sabretooth | Juggernaut | Sentinels | Ahab | Mojo
X-Men 2: Clone Wars: Apocalypse | Phalanx | The Brood | Magneto
X-Men: Children of the Atom: Magneto | Juggernaut | Omega Red | Silver Samurai | Sentinel | Spiral | Mojo
X-Men (1994): Magneto | Sebastian Shaw | Callisto | Sauron | Brood Queen | Omega Red
X-Men 2: Game Master's Legacy: Gamesmaster | Apocalypse | Mister Sinster | Exodus
X-Men: Mutant Apocalypse: Apocalypse | Juggernaut | Omega Red | Brood Queen | Sentinels | Acolytes | Exodus | Magneto
X-Men vs. Street Fighter: Apocalypse | Acolytes | Magneto | Juggernaut | Sabretooth | Rogue | Angel
X-Men 3: Mojo World: Mojo | Magneto | Master Mold | Trevor Fitzroy | Spiral
X-Men: The Ravages of Apocalypse: Apocalypse | Mister Sinister | Magneto
X-Men: Mutant Academy: Magneto | Mystique | Sabretooth | Toad
X-Men: Mutant Wars: Magneto | Mystique | Sabretooth | Apocalypse
X-Men: Wolverine's Rage: Lady Deathstrike | Sabretooth | Deadpool
X-Men: Mutant Academy 2: Magneto | Mystique | Sabretooth | Juggernaut | Toad
X-Men: Reign of Apocalypse: Apocalypse | Archangel | Magneto | Dark Phoenix | Juggernaut | Sabretooth | Silver Samurai | Sauron | Blob | Pyro
X-Men: Next Dimension: Brotherhood of Evil Mutants (Magneto, Sabretooth, Toad, Mystique, Juggernaut, Blob, Lady Deathstrike & Pyro) | Bastion | Sentinels
X2: Wolverine's Revenge: Magneto | Sabretooth | Wendigo | Lady Deathstrike | Juggernaut | Omega Red | Apocalypse | Mr. Sinister
X-Men Legends: Brotherhood of Evil Mutants/Acolytes (Magneto, Mystique, Blob, Pyro, Avalanche, Sabretooth & Toad) | Marrow | Juggernaut | Shadow King | Apocalypse | Master Mold
X-Men Legends II: Rise of Apocalypse: Apocalypse | The Brood | Lady Deathstrike | Sauron | Omega Red | Stepford Cuckoos | Deadpool | Mister Sinister | Dark Beast | Living Monolith | Mystique | Destiny | Blob | Emma Frost | Sebastian Shaw | Archangel | Selene Gallio | Quicksilver
X-Men The Official Game: Brotherhood of Mutants (Magneto, Sabretooth & Pyro) HYDRA (Silver Samurai & Deathstike) | Multiple Man | Jason Stryker | Master Mold | Mystique | Toad

See Also
Alpha Flight Villains | Deadpool Villains | Excalibur Villains | New Mutants Villains | Wolverine Villains | X-Factor Villains | X-Force Villains | X-Men Movie Villains

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