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He was a test subject of the Weapon Plus program, the super-soldier program that had created Captain America and would later transform Wolverine into a killing machine.
The enhancing and conditioning process went awry, leaving Nuke seriously deranged.
Later, he would do black ops for the American government.
The Kingpin paid Nuke's handler to unleash Nuke on New York and to take out his enemies but Nuke was defeated and seemingly killed in battle with Daredevil and Captain America.
He would eventually take up the mantle of the Scourge of the Underworld and join the Thunderbolts.
Powers and abilities
Experienced soldier, Nuke was a savage and brutal fighter, and very good with all types of firearms, with the heavy gatling gun Betsy being his weapon of choice, and very deadly in knife combat, he's also an expert in hand to hand combat despite his insanity.
Superhuman Strength: Nuke's bones have been replaced with advanced cybernetic components, granting him superhuman strength on par with Captain America.
Superhuman Durability: Nuke's body is considerably more resistant to physical injury than that of an ordinary human. Nuke's skin has been replaced with an artificial type of plastic that looks identical to human skin but is much more durable.
Healing Factor: Nuke's accelerated metabolism feeds on his increased adrenaline, which enables him to heal from injuries over a good night's sleep.
Fighting Pills: Nuke has a second heart, and takes different colored pills to produce different bodily effects. Nuke's pill colors are: red, for increased adrenaline; white, to bring him down; and blue, to relax.
Betsy: Nuke used a large gatling gun nicknamed "Betsy" in his missions. Besides conventional machine gun ammunition, Betsy also held six light artillery rounds and two incendiary missiles. On Betsy's side Nuke used an LED counter to count the number of kills he did with his weapon. Nuke also had an unmarked military helicopter for air support, operated by an unnamed colonel. Frank is also equipped with various knives.