Orphan-Maker is the partner-in-crime of Nanny in the X-Men universe, and much like her, is a misguided villain who thinks he is liberating young mutants via forcibly taking them from their parents and often killing these parents. Needless to say Orphan-Maker's violent methods and madness have made him an enemy of many of Marvel heroes.
Nanny was among the children held there and some of her "Lost" children, but were opposed by Cyclops and Marvel Girl (Jean Grey), then members of X-Factor, who were there to retrieve Cyclops' son. In the course of their battle, Marvel Girl discovered that two of Nanny's "Lost" children were thwarted by Cyclops and Marvel Girl in the heroes that she and the Orphan-Maker were robots.
Along with Nanny, the Orphan -Maker has battled members of the X-Men, X-Factor, the Avengers, Generation X, and the Fantastic Four.