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Owen Cage is one of the two secondary antagonists in HITMAN: Patient Zero campaign (alongside Sister Yulduz) and the final antagonist in the campaign, serving as the main antagonist in its final mission, also named Patient Zero.
He is one of the sleeper agents of the doomsday cult "Liberation" and the one who develops the Nabazov virus, being the campaign's titular Patient Zero of Nabazov Virus.
Owen Cage is the idealistic eco-warrior, driven to extreme measures by what he perceives to be a relentless race towards environmental collapse, driven by a cabal of high-ranked Illuminati members, and coordinated by the Elders of Zion. He espoused his conspiracy theories under the internet name "Black Tide" on a range of internet message boards, before finally making contact with Liberation, based in the Fergana region in Uzbekistan.
Together with Oybek Nabazov, he developed a plan to strike at one of the world's largest cities using a highly infectious hemorrhagic virus. He became Nabazov's partner and main developer of Liberation's bioweapon. After Nabazov's death, Cage infected himself with the virus in order to become its Patient Zero and spread it throughout the world.
After failing to infect Sydney due to his frailing health, Cage was escorted to Gama Facility Hospital in Hokkaido, Japan. There, he was isolated by Klaus Liebleid, one of Ether Corporation's best researchers, who was working on extracting the Nabazov virus from Owen Cage and reverse-engineering it.
After Diana Burnwood discovered that the virus cannot be spreaded if its host was dead, Cage was later assassinated by Agent 47 along with Liebleid and all other infected patients, putting an end to Nabazov's virus conspiracy.
It was later suggested by files in the Ark Society, that the projected of Cage and Nabazov were funded by Providence operatives.
- He was apparently planned to an elusive target known as "The Rogue", according to a list of leaked targets on Reddit.
- Due to him being delirious because of the Nabazov virus. He doesn't react to any distractions and will not spot 47 doing anything illegal.