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Penelope is the main antagonist in the Family Guy episode "Mr. and Mrs. Stewie". She is a cute but evil young girl whom Stewie Griffin falls in love with.

She was voiced by Cate Blanchett, who also played Irina Spalko in Indiana Jones and the Kingdom of the Crystal Skull, Marissa Wiegler in HannaLady Tremaine in Cinderella and Hela in Thor: Ragnarok.


Stewie meets Penelope in the park when he got pushed by a boy. She got revenge on the boy by giving him superglue laced taffy, presumably choking him to death. When Stewie plays at Penelope's house, he discovers that she has the same fascination in weapons as he does. However, she was actually successful in killing her mother unlike Stewie by decapitating her. Stewie instantly becomes infatuated with her, and together they cause chaos in several parts of the world. Brian Griffin notices that Penelope was becoming a bad influence on Stewie despite her cuteness and beauty.

In the past Stewie's ambitions were to rule the world, whereas Penelope wants to cause war, chaos, and destruction to the world for nothing more than personal amusement. When Stewie tells Penelope that Brian told him not to see her anymore, she asks him to kill Brian. Stewie was not able to do the job, so Penelope decided to do it herself.

Stewie intervenes and they both start fighting. They had a laser gun fight, and Penelope trapped Stewie with an anti-gravity gun, and Stewie used a gadget to reverse the polarity of the anti-gravity gun to escape. They both fought over the anti-gravity gun and fought in its beam until they wound up on top of a moving truck. When Stewie gets the upper hand in the fight, Penelope agrees to leave Brian alone. Then she kisses Stewie goodbye and rides off with a smile.





  • It is unknown if she is the one who killed Brian in the episode "Life of Brian," but it was likely just an accident.
  • Penelope's outfit is extremely similar to that of "Eloise."


          Family Guy Logo.svg.png Villains

Griffin/Pewterschmidt Family
Peter Griffin | Lois Griffin | Meg Griffin | Stewie Griffin | Brian Griffin | Francis Griffin | Karen Griffin | Carter Pewterschmidt | Patrick Pewterschmidt | Bertram

Brown-Tubbs Family
Cleveland Brown | Donna Tubbs-Brown | Rallo Tubbs

Recurring Characters
Glenn Quagmire | Ernie the Giant Chicken | Connie DiMico | John Herbert Silverbird | James Woods | Diane Simmons | Joyce Kinney | Car Driver

Guest Star Characters
Mr. Rogers | Gloria Ironbachs | The Man in White | Adolf Hitler | Steve Bellows | Jim Kaplan | Mahmoud | Lana Lockhart | Doug the Pimple | Joan Quagmire | Penelope | Evil Stewie | Rob Gronkowski | Kyle | Sheriff Nichols | Sonja | Franz Gutentag | Charles Yamamoto | Mr. Washee Washee | Jeffery Fecalman | Michael Pulaski | Retep | Darth Stewie | Jabba the Swanson | Emperor Carter | Miss Emily | O.J. Simpson | Liam Neeson | Mel Gibson | Miley Cyrus | Sheldon | Bobby Briggs | Jamie, Karen & Becca | Gretchen Mercer | White Fang | Donald Trump

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