Disease gets a bad rep, don't you think? For being filthy, chaotic. Uh, but, really, that just describes people who get sick. Disease itself... very... pure. Single-minded. Bacteria have one purpose: divide and conquer. That's why, in the end... it always wins.
~ Pestilence to Sam and Dean Winchester.

Pestilence is a supporting antagonist during Season 5 of the television show Supernatural. He is one of the Four Horsemen of the Apocalypse, and is a servant of Lucifer. He is the living embodiment of plague and disease.

He is portrayed by Matt Frewer, who is best known for portraying Max Headroom and also voiced Panic in Disney's Hercules.


Pestilence first appears towards the end of the episode "Hammer of the Gods", taking the appearance of a sickly man arriving at an old country drugstore. He is constantly coughing and sneezing and covers all of the store's products in mucus. He picks up an orange box of flu medicine and asks the clerk if the medicine would make him drowsy, saying he had "a lot of driving to do." The clerk says it doesn't, and he goes up to the counter to pay for the medicine, sneezing in the man's face and covering him in mucus. Afterwards, he leaves the store and drives away, no longer coughing or sneezing, and his car is swarmed by flies.

Pestilence returns in the episode "Two Minutes to Midnight" as the main antagonist, where he is posing as a retirement home's resident doctor under the name "Dr. Green". He is seen examining an elderly patient, infecting her with various diseases and observing the effects they have on her before she dies. When he is alerted by a demon posing as a female nurse that the Winchesters are here, he decides to infect them with various diseases, despite the demon's reminder that Lucifer has ordered them not to be harmed. He greets the Winchesters as they stagger towards his room, suffering from Pestilence's powers and has the demon nurse bring them into the room. He goes on to tell them that he prefers diseases to people, and how he can't understand why God loves something so "messy and weak". As he moves in to finish them off, Castiel arrives and Pestilence is surprised to find that the low-powered angel is now susceptible to his powers. Despite his weakened condition, Castiel manages to cut off his ring finger and kill the demon nurse. As his powers begin to wear off of the trio, he says "It doesn't matter. It's too late," before vanishing.

Sam and Dean later learn that he referred to his and Lucifer's plan to spread the Croatoan virus through shipments of swine flu vaccine. Sam, Castiel and Bobby Singer foil his plan by killing his demons and blowing up the distribution warehouse before the virus can be sent out.

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