Rampage, alongside with his fellow ConstructiconsLong Haul, Mixmaster and Scrapmetal aboard a cargo ship. Ravage, who was sent by Soundwave, landed there and called them in to help him dive into the depths of the Laurentian Abyss to revive Megatron. Upon arriving there, Scalpel examined Megatron and then stated they need a small Construction to serve as extra spare parts for them to revive him. Rampage, Long Haul, and Mixmaster then kill Scrapmetal to use him for the spare parts and then Scalpel injects the shard to revive him, which is a success.
During the fight in Egypt, Rampage's yellow painted limb counterpart then combines with the other Constructicons to form Devastator, who then attack Leo Splitz, Seymour Simmons, Mudflap, and Skids. The red Rampage, also known as "Skipjack", was ordered by Starscream to set their trap for Samuel James Witwicky: his parents were being held, hostage. Sam was willing to exchange the remains of the Matrix to save his parents, while Bumblebee strategized to attack him. After a long fight that also killed Ravage, Bumblebee finishes Rampage off by ripping off his arms and over-extending his neck with a powerful kick, killing him. Devastator, in turn, was killed by being hit by the US Navy's experimental railgun, that hit him.
Long Haul, Rampage & Mixmaster witnessing the revival of Megatron.
Rampage being the left leg also pays homage to Bonecrusher's depiction in Transformers: Energon, as well as his toy depiction in Classics (which is a redeco of his Energon incarnation).
Outside the film series, Rampage is a member of the Predacons, a Decepticon combiner group that transforms into robotic wild animals that formed Predaking & his original alt mode is a robotic tiger & forms his arms. This makes Rampage the first Transformer in the entire film series to be portrayed as a member of a different Transformer group compared to G1, with Strafe (a Dinobot in the fourth film who is a Technobot in G1) as the second.
His red color scheme, as well as having a few yellow scheme in the toyline is also a reference to his G1 counterpart.