Villains Wiki

Hi. This is Thesecret1070. I am an admin of this site. Edit as much as you wish, but one little thing... If you are going to edit a lot, then make yourself a user and login. Other than that, enjoy Villains Wiki!!!


Villains Wiki
Villains Wiki

Chemical weapons, human experimentation, SANCTUS was -- is the darkest part of the Agency's history... This place is just evil.
~ Special Agent Iman Avesta on SANCTUS.

SANCTUS is a major or secondary antagonistic faction in Batman: The Enemy Within, the second season of Batman: The Telltale Series.

They are a criminal organization that were once a former black ops science division for The Agency that split from them on the account of the former's viciousness and unethical experiments. From there, they went underground to continue their immoral experiments.


Little about the history of SANCTUS is known, but apparently they were once part of the clandestine government organization known as The Agency. Specializing in scientific fields, SANCTUS would conduct black ops experiments for the Agency. They even brought the Gotham City super-criminal known as The Riddler into their ranks following his promotion sometime after the Agency recruited him because of his criminal history and ambitious vision, with Riddler being given a fortune and promised a better future in life. Riddler quickly developed a prestige career in the Agency, which resulted in his promotion to a SANCTUS scientist. Riddler helped SANCTUS by collaborating on their genetic engineering and biochemical weaponization projects, including Project LOTUS. The project involved SANCTUS hoping to turn an enhanced chemical serum known as the LOTUS Virus into something that healed and strengthened the human body to levels of supernatural perfection rather than quickly or slowly ravage it to death.

However, all of the attempts were initially failures which resulted in the deaths of all human test subjects... until Riddler himself was exposed to it, albeit accidentally. However, instead of dying like the other test subjects, Riddler survived, though was driven to permanent insanity, with his body became enhanced to possibly superhuman levels. Experimented on and turned into a guinea pig, Riddler eventually escaped, seething with hatred for SANCTUS but also blaming it's parent organization for it's actions. Thus, Riddler vowed to destroy the Agency while SANCTUS went underground after being cut loose from the Agency when the latter attempted to rectify their mistakes. From there, they became the organization they are as of the events of the games, continuing their work on the LOTUS Virus and trying in vain to repeat their one-time success with Riddler.

Each respectively suffering from an addiction to the super-steroid Venom, a hereditary mental illness that she did not wish to inherit, and a terminally ill wife in need of a cure, the supervillains Bane, Harley Quinn, and Mr. Freeze joined forces with the Riddler, to each get what they wanted; Riddler, his revenge, and the other three, the means by which to make a "miracle cure" using a combination of the LOTUS Virus and Riddler's own blood, while their friend John Doe, a former patient at Arkham Asylum, preferred to get what he wants through different means instead of through the virus. Little did any of them know that even the "success" of Riddler was in fact another failure: the virus, though indeed enhancing his physical abilities, also did irreparable damage to his mind, making him progressively more aberrant, psychotic, and violent. 

Ultimately, Bruce Wayne comes to join the Pact undercover at the Agency's request. During the time he spends with the Pact and working with Amanda Waller and the Agency, Bruce learns much of the above (including Catwoman's involvement), before finally getting the rest of the story after the Pact assault SANCTUS' Gotham black-site underneath the seemingly ordinary Bodhi Spa. By this point, between the efforts of the Pact and also the Agency (especially if Bruce earlier broke his cover and thus caused the villains to get there ahead of him and slaughter numerous SANCTUS personnel), the organization appears to be at last disbanded. Waller expresses her intent to salvage some of their technology for her own use, which Bruce/Batman can either support or fight against.


  • As a criminal organization involved in human experiments and unethical practices that create multiple supervillains who work for them before breaking away later, they could be likened to Weapon X from Marvel Comics. Both are also opposed by both government organizations (SHIELD and the Agency), and superheroes (Wolverine, the X-Men, and Batman).
  • Likewise, as a criminal organization once part of a greater organization that broke away from them and from there went on to perform many unethical and immoral experiments on humans that created at least one vengeful survivor, they are also somewhat similar to Cerberus from Mass Effect (especially since both are villainous organizations in roleplaying video games).


           Telltale Games.png Villains

Sam & Max
Sam & Max Save the World: Toy Mafia (Hugh Bliss) | Brady Culture
Sam & Max Beyond Time and Space: Soda Poppers | Jurgen
Sam & Max: The Devil's Playhouse: The Narrator | General Skun-ka'pe | Anton Papierwaite | Sammun-Mak | "Junior" Max | Charlie Ho-Tep

Jurassic Park: The Game
Billy Yoder | Laura Sorkin | Miles Chadwick

Strong Bad's Cool Game for Attractive People
Strong Bad | The King of Town | Sultry Buttons | Uzi Bazooka | Craig | Trogdor

The Walking Dead: The Telltale Series
Season One: Walkers | Stranger | Save-Lots Bandits | St. John Family (Andrew | Dan | Brenda) | Bandit Leader | Linda | Jolene | Vernon | Crawford Oberson | Logan | Larry | Lilly | Kenny
400 Days: Walkers | Marcus Crabtree | Nate | Russell | Roman
Season Two: Walkers | William Carver | Arvo | Carver's Group (Troy | Johnny) | Buricko | Vitali | Natasha | Winston | Victor | Ralph | Michelle | Kenny | Jane | Mike
Michonne: Walkers | Norma | Randall | Monroe Colonists (Gabby | Jonas)
A New Frontier: Walkers | Joan | The New Frontier | Badger | Max | Scavenger
The Final Season: Walkers | Lilly | The Delta (Minerva | Abel | Dorian | Sullene | Gad | Michael | Gina | Armando) | Marlon | Violet

The Wolf Among Us: A Telltale Games Series
Bigby Wolf | Crooked Man | Bloody Mary | Jersey Devil | Georgie Porgie | Vivian | Bluebeard | Ichabod Crane | Grendel | Jack Horner | Woodsman | The Tweedles | Geppetto

Tales from the Borderlands: A Telltale Games Series
Rhys | Fiona | Handsome Jack AI | August | Hugo P. Vasquez | Vallory | Bossanova | Rudiger

Game of Thrones: A Telltale Games Series
Asher Forrester | Andros | Britt Warrick | Damien | Dezhor zo Raza | Gared Tuttle | Gryff Whitehill | Harys | Ludd Whitehill | Rickard Morgryn | Tazal

Minecraft: Story Mode
Romeo | Hostile Mobs | The Ocelots | Ivor | Wither Storm | Soren the Architect | Aiden | Maya | Gill | White Pumpkin | PAMA | Hadrian | Mevia | Em | Stella | Prismarine Foes | Warden

Batman: The Telltale Series
Gotham Criminal Triumvirate: Thomas Wayne | Hamilton Hill | Carmine Falcone
Children of Arkham: Lady Arkham | Penguin | Blockbuster
The Pact: Riddler | Harley Quinn | Bane | Mr. Freeze | Joker
The Agency: Amanda Waller | Roger Harrison
Others: Catwoman | Two-Face | Joe Chill | Victor Zsasz | The Vales | Deadshot | Black Spider | Rumi Mori | Eli Knable | Willy Deever | SANCTUS

See Also
Jurassic Park Villains | Homestar Runner Villains | The Walking Dead: The Telltale Series Villains | Game of Thrones Villains | Minecraft Villains | Batman: The Telltale Series Villains

           Batman Telltale logo.png Villains

Gotham Criminal Triumvirate
Thomas Wayne | Hamilton Hill | Carmine Falcone

Children of Arkham
Lady Arkham | Penguin | Blockbuster

The Pact
Riddler | Harley Quinn | Bane | Mr. Freeze | Joker | Eli Knable

The Agency
Amanda Waller | Roger Harrison

Catwoman | Two-Face | Joe Chill | Victor Zsasz | The Vales | Deadshot | Black Spider | Rumi Mori | Willy Deever | SANCTUS