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"Sam" may be referring to two or more different villains. If you're uncertain which one you're looking for, just flip a coin. If you came here from a link, please go back and make the right link for one of the villains listed below.
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Sam may refer to:
- Dr. Sam Isaacs - A character from the Resident Evil film series
- Hon Sam - A character from The Infernal Affairs Trilogy
- SAM - The villain in the computer game 7Days
- Samantha Maxis - a major antagonist of Call of Duty Zombies series who turned into a protagonist.
- Sam (Mafia) - A character in Mafia: The City of Lost Heaven and it's 2020 remake.
- Sam (Trick 'r Treat) - A character from Trick 'r Treat
- Sam Choksey - A character from The Wire
- Sam Harper - The main villain of the 1996 slasher film Uncle Sam.
- Sam Lesser - The secondary antagonist in Locke & Key.
- Sam Lesser (TV Series) - His Netflix counterpart.
- Sam Miller - A one-time character in Dhar Mann.
- Sam Scott - The main antagonist of CASE: Animatronics.
- Sam Strong The main protagonist villain of Beneath the Trees Where Nobody Sees.
- Sergeant Sam Roderick - A character from Spongebob Squarepants
- Sam Wescott - The protagonist from You Might Be the Killer
- Yosemite Sam - A character from Looney Tunes
- Sam (Honkai: Star Rail) - A major antagonist in Honkai: Star Rail
- Sam (Ultimate Town Sandbox) - A playable character in the Roblox game Ultimate Town Sandbox