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Donna became a security guard for the Life Foundation. As part of their program to create a super-powered security force, the Life Foundation scientist merged the resulting creatures with five of their most skilled and trusted employees. One of those employees was Donna. She fled back to the Life Foundation's base in the Mojave Desert. Spider-Man stowed away on her hovercraft and released Brock. Diego and the other new symbiotes lost the resulting battle, and they apparently died from accelerated aging when Brock used a metabolic accelerator on them. Her symbiote was turned into dust and her body caught in a massive explosion.
It was later revealed that Donna left with their immature symbiotes and hoped that Brock would work with them so as to teach them control. Brock refused and Diego had a psychotic episode and went wild in Times Square. She succeeded in drawing the attention of Brock and Reilly. Brock fought with Diego, and only the intervention of Reilly saved her.
The other "guardian" symbiotes took him to Chicago. He managed to escape. Brock reunited with Venom before Diego could kill him as well and defeated her.
Diego somehow gained a measure of control over her symbiote, or at least reached a modus vivendi with it. To make up for her past behavior, she began seeking out other symbiotes and helping their human hosts to cope. She soon learned of an alien called Xenophage that preyed on symbiotes. With Brock's help she defeated it.
In Diego's most recent appearance, she found the Xenophage's ship. Along with Brock and Wolverine, she traveled to an alien dimension and returned safely to Earth.
Donna Diego met her demise in a most void manner: while investigating the murder of Scott Washington (a deceased host to Symbiote Hybrid), she was lured into a trap by obsessed and Symbiote-less Eddie Brock, who got brainwashed by a villain named Crime Master into hating everything Symbiotes, went on hunting of Symbiotes. Using a sonic emitter, he paralyzed her and slew her with a heated dagger. It was a thankless end for a woman who was beginning to learn to be a heroine.
Years later, seemingly forgotten, Scream would be resurrected by her older sibling Carnage, now under the thrall of Knull, the Symbiote God, and used her as a general and leader in his Symbiote armies, intending to hunt down the Codexes of other Symbiote hosts and devour their spines to awaken Knull. Scream would bond with former Venom/Mania host Patricia Robertson, and drawn by both Patricia's memories, and Carnage's orders, would seek out second Mania host, Andrea Benton. Taking on Donna's personality, Scream was overwhelmed by voices, and fell to Knull, attacking Andi before Patricia got her under control. Carnage would arrive in person, and cause Scream to once more fall under control.
Carnage would bring both sibling and Andi to a meat plant, intending to butcher Andi, before Scream overcame her control and attacked Carnage a second time. After an extended battle, Patricia would sacrifice her life to make sure Andi and Scream escaped Carnage and managed to make it out alive.
After escaping Carnage and his cult, Andi and Scream would remain bonded, but their connection was far more hostile and less amicable then Andi's connection with Mania. Andi, depressed and withdrawn, refused to accept Scream, demanding the Symbiote abandon her like everyone else in her life, and even attempting suicide, before the Symbiote would stop her. As they struggled to find their place, Andi would frequent the F.E.A.S.T shelter, while another figure made their move.
Several days in a row, creatures crafted from Symbiote offshoots, combined with sea creatures, corpses left in the ocean and refuse would be fused together into foot soldiers, and sent after Scream, ambushing her on the streets and in the shelter, Scream fighting them off each time, and devouring one, briefly falling under Knull's influence a third time, but now aware of where their enemy was hiding. Traveling to the ocean, Scream would go down beneath the waves, and make her way to the deepest parts, before encountering the Symbiote Dragon Big Momma (Symbiote).
Having been left in ice for years and only recently reawakening, the Big Momma Symbiote was a sibling to the Grendel Symbiote. She had awakened earlier, but became aware of Grendel/Carnage's activity, and desired to assist, but was too late. She lay in wait in the Hudson Bay, building an army to await Knull's arrival, and desired to draw Scream to her. After fighting through her servants, Scream confronted the monolithic Symbiote dragon, who proceeded to try and separate them. She explained her desire to have a daughter, in Scream, and that she needed to be rid of her host when Knull came. Countless times she tore them off, utilizing her brute strength and void-born powers to attack them, and everytime they managed to outmanuever each other and rebound.
Scream was one of the five Life Foundation Symbiotes that were forcefully spawned from the Venom symbiote. Unlike her "brothers", she wasn't merged into the Hybrid symbiote, being still at large at the time.
Scream was created by David Michelinie and Ron Lim.